DUSP4 Inhibitors
DUSP4 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of DUSP4, which stands for Dual-Specificity Phosphatase 4. DUSP4 is part of the larger family of dual-specificity phosphatases, which are responsible for dephosphorylating both serine/threonine and tyrosine residues on proteins. DUSP4 primarily acts on members of the mitogen-activated protein kinase (MAPK) family, such as ERK, JNK, and p38, by removing phosphate groups, thus regulating signal transduction pathways. These pathways are involved in controlling various cellular processes, including growth, differentiation, and stress responses. By inhibiting DUSP4, these inhibitors interfere with the phosphatase's ability to deactivate MAPKs, potentially altering the phosphorylation state of these proteins and affecting downstream signaling cascades.
Structurally, DUSP4 inhibitors are designed to interact with the active site of the enzyme, where the dephosphorylation of MAPKs occurs. These inhibitors can function through competitive inhibition, where they block the enzyme's access to its substrate, or they can target allosteric sites that cause conformational changes, reducing the phosphatase's enzymatic activity. The study of DUSP4 inhibitors is critical for understanding the regulatory role of DUSP4 in MAPK-mediated signal transduction. By inhibiting DUSP4, researchers can examine how changes in phosphorylation dynamics influence various cellular processes, offering insights into the delicate balance of kinase and phosphatase activities in cell signaling. This provides a deeper understanding of how DUSP4 contributes to the control of cellular responses to external and internal signals, and how its inhibition affects the broader regulatory networks that maintain cellular function and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could downregulate DUSP4 expression by inhibiting the transcriptional activity of AP-1, a factor that can upregulate DUSP4, and by curbing the activation of JNK and p38 MAPK, pathways that are known to increase DUSP4 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may decrease DUSP4 expression by enhancing SIRT1 activity, which in turn deacetylates and represses p65 subunit of NF-κB, leading to reduced transcription of NF-κB target genes, including DUSP4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could reduce DUSP4 expression by inhibiting the activation of the EGFR and subsequent MAPK/ERK pathway, which may otherwise stimulate the transcription of DUSP4 in response to growth signals. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein may decrease DUSP4 expression by blocking tyrosine kinase receptors, resulting in the suppression of the MAPK/ERK pathway; this cascade is often responsible for the upregulation of DUSP4 in response to extracellular signals. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could downregulate DUSP4 expression by inhibiting the phosphorylation of STAT3, a transcription factor that, when activated, can promote the transcription of various genes, including DUSP4. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may suppress DUSP4 expression by activating the Nrf2 transcription factor, which then induces the expression of detoxifying enzymes, potentially creating a cellular environment that is less conducive to DUSP4 transcription. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol can decrease DUSP4 expression by promoting the breakdown of estrogen to less active metabolites, consequently lowering the activation of estrogen receptor signaling pathways that can enhance DUSP4 expression. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol might inhibit DUSP4 expression by inhibiting the phosphorylation and activation of ERK1/2, which are known to drive the transcription of DUSP4 in a feedback loop mechanism to modulate the MAPK signaling pathway. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin could reduce the expression of DUSP4 by directly inhibiting PI3K, an upstream activator of AKT signaling, which has been implicated in the transcriptional control of various genes, including those for phosphatases like DUSP4. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid may downregulate DUSP4 through the inhibition of STAT3 activation, which is required for the expression of a subset of genes during an inflammatory response, possibly including DUSP4. | ||||||