Date published: 2026-1-12

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DPY19L3 Activators

DPY19L3 activators are a specialized category of compounds that target the DPY19L3 gene product, a protein believed to be involved in the molecular biology of cells. The gene DPY19L3 encodes a protein that is part of a family characterized by their specific functions in cellular mechanisms. The precise biochemical pathways that these activators influence are complex and multifaceted. Activators in this class are designed to increase the activity of the DPY19L3 protein. They may work by promoting the protein's stability, enhancing its expression, or by facilitating its proper localization within the cell. The action of these activators is highly specific, which requires an intricate understanding of the protein structure and the cellular context in which it operates. By binding to the DPY19L3 protein or influencing the cellular machinery that regulates its activity, these activators can fine-tune the protein's function.

The discovery and development of DPY19L3 activators involve sophisticated research techniques. Often, the process begins with the use of high-throughput chemical screens to identify candidate molecules that can increase the activity of the DPY19L3 protein. Once potential activators are identified, rigorous biochemical assays are employed to confirm and quantify their activating effects. Further refinement of these molecules typically follows, using a combination of synthetic chemistry and structure-activity relationship studies to enhance their potency and selectivity. Researchers also utilize advanced computational tools to model how these activators might interact with the DPY19L3 protein at an atomic level, which can provide insights into the molecular basis of their function. This information is invaluable for the iterative process of molecular optimization that is central to the development of these compounds. Through these comprehensive approaches, scientists aim to elucidate the regulatory mechanisms of the DPY19L3 protein and to harness the ability to modulate its activity with a high degree of precision.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

Tunicamycin inhibits N-linked glycosylation, which may trigger a cellular response to upregulate DPY19L3 as a compensatory mechanism.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

As an ER stress inducer by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), it may enhance DPY19L3 expression as part of the unfolded protein response.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

This compound disrupts ER to Golgi transport, potentially increasing DPY19L3 expression to maintain glycosylation under stress conditions.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 inhibits proteasomes, causing protein accumulation and potential upregulation of DPY19L3 as a stress response.

β-Mercaptoethanol

60-24-2sc-202966A
sc-202966
100 ml
250 ml
$90.00
$120.00
10
(2)

This reducing agent can disrupt disulfide bonds, potentially enhancing DPY19L3 expression to manage misfolded proteins in the ER.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

As an autophagy inhibitor, chloroquine might upregulate DPY19L3 expression by affecting protein degradation pathways.

Emetine

483-18-1sc-470668
sc-470668A
sc-470668B
sc-470668C
1 mg
10 mg
50 mg
100 mg
$440.00
$900.00
$1400.00
$2502.00
(0)

This alkaloid inhibits protein synthesis, which could result in compensatory upregulation of proteins involved in glycosylation, like DPY19L3.

Sodium (meta)arsenite

7784-46-5sc-250986
sc-250986A
100 g
1 kg
$108.00
$780.00
3
(2)

Sodium arsenite induces oxidative stress, potentially increasing DPY19L3 expression as part of a cellular protective response.

Cadmium chloride, anhydrous

10108-64-2sc-252533
sc-252533A
sc-252533B
10 g
50 g
500 g
$56.00
$183.00
$352.00
1
(1)

Cadmium is known to induce ER stress, which might lead to an upregulation of DPY19L3 in an attempt to restore normal ER function.

Sodium phenylbutyrate

1716-12-7sc-200652
sc-200652A
sc-200652B
sc-200652C
sc-200652D
1 g
10 g
100 g
1 kg
10 kg
$77.00
$166.00
$622.00
$5004.00
$32783.00
43
(1)

This chemical chaperone helps in reducing ER stress, which might signal the upregulation of DPY19L3 expression.