DPY19L3 activators are a specialized category of compounds that target the DPY19L3 gene product, a protein believed to be involved in the molecular biology of cells. The gene DPY19L3 encodes a protein that is part of a family characterized by their specific functions in cellular mechanisms. The precise biochemical pathways that these activators influence are complex and multifaceted. Activators in this class are designed to increase the activity of the DPY19L3 protein. They may work by promoting the protein's stability, enhancing its expression, or by facilitating its proper localization within the cell. The action of these activators is highly specific, which requires an intricate understanding of the protein structure and the cellular context in which it operates. By binding to the DPY19L3 protein or influencing the cellular machinery that regulates its activity, these activators can fine-tune the protein's function.
The discovery and development of DPY19L3 activators involve sophisticated research techniques. Often, the process begins with the use of high-throughput chemical screens to identify candidate molecules that can increase the activity of the DPY19L3 protein. Once potential activators are identified, rigorous biochemical assays are employed to confirm and quantify their activating effects. Further refinement of these molecules typically follows, using a combination of synthetic chemistry and structure-activity relationship studies to enhance their potency and selectivity. Researchers also utilize advanced computational tools to model how these activators might interact with the DPY19L3 protein at an atomic level, which can provide insights into the molecular basis of their function. This information is invaluable for the iterative process of molecular optimization that is central to the development of these compounds. Through these comprehensive approaches, scientists aim to elucidate the regulatory mechanisms of the DPY19L3 protein and to harness the ability to modulate its activity with a high degree of precision.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which may trigger a cellular response to upregulate DPY19L3 as a compensatory mechanism. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
As an ER stress inducer by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), it may enhance DPY19L3 expression as part of the unfolded protein response. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts ER to Golgi transport, potentially increasing DPY19L3 expression to maintain glycosylation under stress conditions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits proteasomes, causing protein accumulation and potential upregulation of DPY19L3 as a stress response. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
This reducing agent can disrupt disulfide bonds, potentially enhancing DPY19L3 expression to manage misfolded proteins in the ER. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
As an autophagy inhibitor, chloroquine might upregulate DPY19L3 expression by affecting protein degradation pathways. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
This alkaloid inhibits protein synthesis, which could result in compensatory upregulation of proteins involved in glycosylation, like DPY19L3. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite induces oxidative stress, potentially increasing DPY19L3 expression as part of a cellular protective response. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium is known to induce ER stress, which might lead to an upregulation of DPY19L3 in an attempt to restore normal ER function. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
This chemical chaperone helps in reducing ER stress, which might signal the upregulation of DPY19L3 expression. | ||||||