DPEP2 Inhibitors

DPEP2 inhibitors function primarily by inhibiting key processes and pathways that DPEP2 is involved in. Valproic Acid, an inhibitor of histone deacetylases (HDACs), can potentially lead to the sequestration of DPEP2 in the nucleus, thereby decreasing its functional activityin the cytoplasm. On the other hand, Acivicin, a glutamine amidotransferase inhibitor, can decrease the availability of glutamine, a critical amino acid for DPEP2 activity. Similarly, Methotrexate, an inhibitor of dihydrofolate reductase (DHFR), indirectly affects DPEP2 function by inhibiting nucleotide synthesis which is crucial for DPEP2's role in peptide metabolism.

Other inhibitors such as Sulfasalazine, Isoniazid, Chloramphenicol, and Streptomycin influence DPEP2 indirectly by altering the immune response to bacterial infections. By suppressing the immune response or interfering with bacterial protein synthesis, these inhibitors can affect DPEP2's functional activity. Meanwhile, 3-Methyladenine, Bafilomycin A1, Chloroquine, Lys05, and Spautin-1 inhibit autophagy, a cellular process that DPEP2 may be involved in. These inhibitors block autophagy at different stages, thereby potentially decreasing the functional activity of DPEP2.