DnaJC9 Activators

The category of DnaJC9 Activators embraces chemicals that tap into the realm of cellular stress, especially emphasizing the heightened need for chaperone proteins like DnaJC9 during such stress scenarios. Two key sub-categories that emerge within this ensemble of chemicals are HSP90 inhibitors (like Geldanamycin, 17-AAG, and Radicicol) and inducers of ER stress (like Thapsigargin and Tunicamycin). HSP90 inhibitors are noteworthy because the inhibition of HSP90 can indirectly augment the demand for HSP70 and its associated co-chaperones, such as DnaJC9, to maintain proteostasis.

Similarly, chemicals that instigate ER stress, such as Thapsigargin and Tunicamycin, underscore the essential role of chaperones within the endoplasmic reticulum. The blockade of N-linked glycosylation by Tunicamycin or the disturbance of calcium homeostasis by Thapsigargin can create a backlog of misfolded proteins, subsequently leading to an escalated demand for chaperones, possibly DnaJC9, to reinstate cellular balance. Furthermore, proteasome inhibitors, such as MG132 and Bortezomib, highlight another aspect of protein quality control. By inhibitng the degradation of misfolded proteins, these chemicals can indirectly elevate the requirement for DnaJC9 to assist in the folding or refolding of these accumulated proteins.