Diva activators represent a class of chemical compounds designed to modulate the activity of Diva, an acronym for DNA-Binding Diva (Diva) protein. The Diva protein, also known as CIDEA (Cell Death-Inducing DFFA-Like Effector A), belongs to a family of proteins known as cell death-inducing DFFA-like effector (CIDE) proteins. These proteins are involved in various cellular processes, including lipid metabolism, apoptosis, and cell death regulation. Diva, specifically, has garnered significant attention for its role in lipid droplet dynamics and adipose tissue metabolism, making it a key player in metabolic pathways.
Diva activators are meticulously engineered to interact with Diva and influence its cellular functions. By targeting Diva, these compounds may modulate its involvement in lipid metabolism and its interactions with other proteins or molecules within cells. Research on Diva activators offers valuable insights into the intricate mechanisms governing lipid storage and utilization in adipose tissue and other cell types. Understanding the molecular basis of Diva activation is essential for unraveling the complexities of metabolic regulation and its implications for overall health and metabolic diseases. Further investigation is needed to elucidate the precise mechanisms of action and biological consequences associated with Diva activation, providing a deeper understanding of cellular physiology and the regulation of lipid metabolism.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide induces DNA damage, which can activate apoptotic pathways and potentially upregulate Diva/BAD expression as part of the cellular response. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor that induces apoptosis, possibly leading to increased Diva/BAD expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA replication enzymes, causing DNA damage and possibly upregulating Diva/BAD in response. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide generates oxidative stress, which can induce apoptosis and Diva/BAD expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress, which may lead to the upregulation of pro-apoptotic proteins like Diva/BAD. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis, inducing stress responses that could elevate Diva/BAD expression. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite causes cellular stress and may enhance Diva/BAD expression as a result. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can induce apoptosis in certain cells, potentially affecting Diva/BAD levels. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor that may lead to apoptosis and an increase in Diva/BAD expression in certain cancer cells. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts p53-MDM2 interaction, potentially enhancing apoptosis and Diva/BAD expression. |