DGK-η Activators
Compounds like PMA, Lithium Chloride, and Caffeine indirectly affect DGK-η activity as DGK-η Activators as they change the levels of diacylglycerol (DAG), the primary substrate for DGK-η. PMA, through PKC activation, and Lithium Chloride, via alterations in the phosphoinositide pathway, impact DAG metabolism. Caffeine's inhibition of phosphodiesterases leading to altered cAMP levels also plays a role in signaling pathways involving DGK-η.
Compounds such as Forskolin, Bisindolylmaleimide I, and U73122, affect intracellular signaling molecules like cAMP and enzymes like PLC, which are crucial in the pathways involving DAG metabolism. Forskolin's elevation of cAMP levels and U73122's inhibition of PLC are particularly notable for their indirect effects on DGK-η activity. Additionally, broader spectrum agents like Staurosporine and Wortmannin, which target multiple kinases and PI3K respectively, demonstrate the intricate network of signaling pathways that can influence DGK-η's role in lipid signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can indirectly enhance DGK-η activity by increasing DAG levels, a substrate for DGK-η, thus potentially boosting its activity in signal transduction. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium modulates the phosphoinositide pathway. By altering phosphoinositide metabolism, it can indirectly influence DGK-η activity due to its role in DAG metabolism. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels, which can indirectly influence DGK-η activity by modulating cAMP-dependent signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels by activating adenylate cyclase. Elevated cAMP can indirectly enhance DGK-η activity by affecting signaling pathways that involve DAG metabolism. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM is a PKC inhibitor. By inhibiting PKC, it can lead to altered DAG levels, which may indirectly enhance DGK-η activity by altering its substrate availability. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol, a beta-blocker, can influence signaling pathways involving cAMP and potentially affect DGK-η activity through its role in DAG metabolism. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, which can indirectly influence DGK-η activity by affecting signaling pathways involving phosphatidylinositol metabolism, a pathway closely related to DAG metabolism. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, affecting multiple signaling pathways and potentially influencing DGK-η activity by altering the phosphorylation status of key signaling molecules. | ||||||