δ-sarcoglycan Activators
δ-Sarcoglycan activators comprise a category of chemical agents that target and modulate the activity of the δ-sarcoglycan protein, a crucial component of the sarcoglycan complex found in the membrane of muscle cells. The sarcoglycan complex is a subcomplex of the dystrophin-glycoprotein complex (DGC), which connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix and is critical for maintaining the integrity of the muscle membrane during contraction.
Direct activators of δ-sarcoglycan interact with the protein to enhance its natural function, potentially by stabilizing its structure or its association with other components of the DGC. This stabilization is essential for the maintenance of muscle fiber stability and could help in promoting the mechanical support that muscle fibers require during contraction and relaxation cycles. Indirect activators might influence the expression or stability of δ-sarcoglycan through several possible mechanisms. They could act by upregulating the transcription of the gene encoding δ-sarcoglycan, thereby increasing its protein levels in muscle cells. They might also affect the post-translational modification of the protein, which could include alterations in phosphorylation states, glycosylation patterns, or ubiquitination levels, all of which can affect δ-sarcoglycan's stability and interaction with other proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, thereby increasing intracellular levels of cAMP. Increased cAMP levels can stimulate the signaling pathways downstream of the δ-sarcoglycan receptor, leading to its activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is a potent activator of the EP2 and EP4 receptors, which are known to increase the intracellular cAMP levels. This can enhance the δ-sarcoglycan signaling pathway, leading to the activation of δ-sarcoglycan. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist, leading to elevated cAMP levels. This can stimulate the δ-sarcoglycan signaling pathway, thereby activating δ-sarcoglycan. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, which results in an increase in intracellular cAMP levels. Elevated cAMP levels can enhance the signaling pathways downstream of the δ-sarcoglycan receptor, leading to the activation of δ-sarcoglycan. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can interact with several G-protein coupled receptors, influencing cAMP levels. This impact on cAMP levels can modulate the δ-sarcoglycan signaling pathway, leading to the activation of δ-sarcoglycan. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine interacts with G-protein coupled receptors, including H1 and H2, leading to changes in cAMP levels. This can stimulate the δ-sarcoglycan signaling pathway, leading to the activation of δ-sarcoglycan. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine modulates various adenosine receptors, which can influence cAMP levels. This modulation can stimulate the δ-sarcoglycan signaling pathway, leading to the activation of δ-sarcoglycan. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits cAMP phosphodiesterase, leading to increased intracellular cAMP levels. Elevated cAMP levels can stimulate the signaling pathways downstream of the δ-sarcoglycan receptor, leading to the activation of δ-sarcoglycan. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is an adrenergic receptor agonist, which can increase cAMP levels. This increase can enhance the signaling pathways downstream of the δ-sarcoglycan receptor, leading to the activation of δ-sarcoglycan. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine can stimulate beta-adrenergic receptors, leading to increased cAMP levels. This increase can stimulate the δ-sarcoglycan signaling pathway, thereby activating δ-sarcoglycan. | ||||||