DDX41 Activators
The DDX41 Activators represent a diverse group of chemicals with distinct mechanisms of action, all capable of modulating cellular processes that indirectly influence the activity of the DDX41 protein. These chemicals span various signaling pathways, offering insights into potential avenues for manipulating DDX41 function in a controlled manner. One such chemical, A769662, acts as an activator of AMP-activated protein kinase (AMPK). By phosphorylating and activating AMPK, A769662 contributes to the regulation of cellular energy homeostasis, suggesting a link between cellular metabolism and DDX41 activity. Similarly, forskolin, through its activation of adenylyl cyclase and subsequent elevation of intracellular cAMP levels, indirectly impacts DDX41 by influencing cAMP/PKA signaling pathways associated with cellular responses. Additionally, the inclusion of 2-Deoxy-D-glucose, a glycolysis disruptor, highlights the potential influence of altered cellular metabolism on DDX41. Cobalt chloride, by stabilizing hypoxia-inducible factor-1α (HIF-1α), creates hypoxia-mimicking conditions, indirectly affecting DDX41 through the modulation of immune responses linked to HIF-1α.
Furthermore, chemicals such as sodium salicylate, nicotinamide, and SB202190 showcase the potential for indirect modulation of DDX41 through inhibition of NF-κB, sirtuins, and p38 MAP kinase, respectively. These chemicals exemplify the intricate connections between DDX41 and key signaling pathways involved in immune responses and stress signaling. The calcium ionophore A23187 and the calcium chelator BAPTA underscore the significance of calcium signaling in influencing DDX41 activity, providing additional layers to our understanding of the protein's regulation. In summary, the DDX41 Activators represent a valuable collection of chemicals that offer a nuanced approach to modulating DDX41 activity indirectly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator. It promotes the phosphorylation and activation of AMPK, which, in turn, can modulate various cellular processes. In the context of DDX41, AMPK activation can indirectly influence the protein by regulating energy homeostasis and cellular stress responses. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased intracellular cAMP levels. Elevated cAMP can activate protein kinase A (PKA) and modulate downstream signaling pathways. In the case of DDX41, forskolin's impact on cAMP/PKA signaling may indirectly influence the protein's activity by affecting cellular processes associated with cAMP-dependent pathways. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that can interfere with glycolysis. Disruption of glycolysis can alter cellular metabolism, influencing AMP levels and energy-sensing pathways such as AMPK. Consequently, the modulation of these pathways by 2-Deoxy-D-glucose may indirectly impact DDX41 activity by altering the cellular environment. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt chloride induces hypoxia-mimicking conditions by stabilizing hypoxia-inducible factor-1α (HIF-1α). This activation of the hypoxia response pathway can indirectly affect DDX41, as HIF-1α is implicated in various cellular processes, including immune responses. The modulation of this pathway by cobalt chloride may lead to changes in the cellular milieu that influence DDX41 function. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a protein tyrosine phosphatase inhibitor. By inhibiting these phosphatases, it can enhance tyrosine phosphorylation and activate signaling pathways involved in cellular responses. In the context of DDX41, sodium orthovanadate may indirectly activate the protein by influencing tyrosine phosphorylation events within signaling cascades associated with its regulation. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium salicylate is a nonsteroidal anti-inflammatory drug (NSAID) that can inhibit the activation of NF-κB, a transcription factor involved in immune responses. Inhibition of NF-κB by sodium salicylate may indirectly influence DDX41 activity by affecting the transcriptional regulation of genes involved in immune and inflammatory processes, in which DDX41 participates. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, is an inhibitor of sirtuins, which are NAD+-dependent deacetylases. Modulation of sirtuin activity by nicotinamide can influence cellular processes related to metabolism and stress responses. Indirectly, this can impact DDX41 by altering the cellular environment and the availability of cofactors involved in processes linked to the protein's function. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
SB202190 is a selective inhibitor of p38 MAP kinase. By blocking p38 MAP kinase activity, SB202190 can affect downstream signaling pathways involved in immune responses and stress signaling. In the context of DDX41, the inhibition of p38 MAP kinase may indirectly modulate the protein's activity by influencing the cellular responses associated with p38 MAP kinase-regulated pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that promotes the influx of calcium ions into cells. Elevated intracellular calcium levels can activate signaling pathways related to immune responses and cell stress. In the case of DDX41, A23187's impact on calcium-dependent pathways may indirectly influence the protein by modulating cellular processes associated with calcium signaling and its downstream effects. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, leading to DNA hypomethylation. Changes in DNA methylation patterns can influence gene expression profiles. In the context of DDX41, the alteration of gene expression by 5-Azacytidine may indirectly impact the protein's activity by affecting the transcriptional regulation of genes involved in pathways related to its function. | ||||||