Dcun1D5 Inhibitors
DDcun1D5 Inhibitors are a class of chemical compounds that indirectly inhibit the functional activity of the protein Dcun1D5 by targeting the ubiquitin-proteasome system (UPS) and neddylation processes in which Dcun1D5 is involved. For example, proteasome inhibitors such as Velcade, MG132, Bortezomib, Carfilzomib, Lactacystin, Epoxomicin, and Clasto-Lactacystin β-lactone work by preventing the degradation of ubiquitinated proteins. Since Dcun1D5 functions as a scaffold protein in the UPS, assisting in the neddylation of cullin-RING ligases, the inhibition of proteasome activity leads to the accumulation of proteins that would normally be ubiquitinated and degraded. This protein accumulation can disrupt the function of UPS components including Dcun1D5, effectively inhibiting its functional activity. The accumulation of substrates due to proteasome inhibition can saturate Dcun1D5's scaffold function, indirectly leading to a decrease in its activity.
Additionally, compounds that specifically target neddylation, such as MLN4924 (Pevonedistat), a NEDD8-activating enzyme inhibitor, and IXA-001, an irreversible inhibitor of the E1 activating enzyme for Nedd8, also decrease the functional activity of Dcun1D5. By inhibiting the enzymes responsible for activating Nedd8, these compounds prevent neddylation, a process critical for the function of cullin-RING ubiquitin ligases, where Dcun1D5 is known to play a role. The prevention of neddylation consequently leads to a decrease in the activity of Dcun1D5, as its function is closely tied to the neddylation state of its substrates. Pyr-41, which acts as a ubiquitin-activating enzyme E1 inhibitor, also contributes to the decrease in ubiquitination and subsequent neddylation processes, thereby reducing Dcun1D5 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Velcade is a proteasome inhibitor that can prevent the degradation of ubiquitinated proteins. Dcun1D5 is known to be a part of the ubiquitin proteasome system (UPS) as a scaffold protein aiding in neddylation, which is crucial for the function of cullin-RING ligases. Inhibition of the proteasome by Velcade can lead to the accumulation of proteins that would normally be degraded, potentially disrupting the function of components of the UPS, including Dcun1D5. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a reversible proteasome inhibitor that blocks the degradation of ubiquitin-conjugated proteins. By inhibiting the proteasome, MG132 can lead to the accumulation of neddylation substrates, thus indirectly inhibiting the functional activity of Dcun1D5 by saturating its scaffold function. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme (NAE) inhibitor that prevents neddylation. Since Dcun1D5 is involved in promoting neddylation, the inhibition of NAE by MLN4924 would decrease the neddylation process and thereby decrease the functional activity of Dcun1D5. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is a ubiquitin-activating enzyme E1 inhibitor, which can block the ubiquitin-proteasome pathway. Inhibiting E1 can lead to a decrease in the ubiquitination and subsequent neddylation processes, thus indirectly decreasing the functional activity of Dcun1D5. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome that irreversibly binds to and inhibits the active site. The inhibition of proteasomal activity can result in the dysfunction of the ubiquitin-proteasome pathway, which in turn can indirectly inhibit the activity of Dcun1D5. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
Carfilzomib is a selective proteasome inhibitor that irreversibly binds to the proteasome's active site. By inhibiting proteasomal degradation, carfilzomib can lead to the dysfunction of ubiquitin-dependent processes, impacting the role of Dcun1D5 in the neddylation pathway. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor that covalently binds to and inhibits the chymotryptic activity of the proteasome. The resulting accumulation of ubiquitinated proteins can indirectly inhibit Dcun1D5 by disrupting the processes it facilitates within the UPS. | ||||||