Dbp5 Activators
Dbp5, also designated as DEAD box polypeptide 5, is an RNA helicase enzyme that is intricately involved in the complex process of RNA transport and metabolism. It is a pivotal component in the intricate system of nucleocytoplasmic transport, playing a crucial role in the export of messenger RNA (mRNA) from the nucleus to the cytoplasm, a fundamental cellular process ensuring proper gene expression and regulation. Beyond its central role in mRNA export, Dbp5 is associated with ribonucleoprotein complex remodeling and has a hand in ribosome assembly, marking its significance across multiple stages of gene expression. The activity and expression of Dbp5 are tightly regulated within the cell, responding to a myriad of intracellular signals and environmental stimuli to maintain cellular homeostasis.
The expression of Dbp5 can be influenced by a variety of chemical compounds, which are often researched within the context of cellular biology and molecular genetics. These compounds can act as activators, modulating the expression of Dbp5 through diverse mechanisms. For instance, certain small molecules might induce the expression of Dbp5 by altering the transcriptional landscape, either through direct interaction with DNA or by modifying the chromatin structure, thereby making the genetic material more accessible for transcription. Other compounds may act indirectly, by triggering signal transduction pathways that converge on the transcriptional machinery, leading to the enhanced expression of Dbp5. These signaling molecules can act as secondary messengers, amplifying the cellular response to an initial stimulus and resulting in the activation of specific transcription factors which target the Dbp5 gene. Furthermore, some activators might exert their effects on Dbp5 expression by influencing post-transcriptional modifications or by stabilizing the mRNA, thus affecting the overall levels of the protein. The study of these chemical activators contributes to a deeper understanding of the regulatory networks governing Dbp5 expression and offers insights into the molecular choreography that orchestrates cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can upregulate gene expression by binding to retinoic acid receptors, which then bind to retinoic acid response elements in the DNA, potentially increasing the transcription of genes such as Dbp5. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates the production of cyclic AMP (cAMP), a secondary messenger that activates protein kinase A (PKA). PKA can then phosphorylate transcription factors, leading to increased transcription of target genes, potentially including Dbp5. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could induce expression of genes by inhibiting histone deacetylase, leading to a more relaxed chromatin state and permitting transcriptional machinery to access genes, potentially stimulating Dbp5 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can induce gene expression by causing DNA demethylation, thereby removing epigenetic silencing marks and permitting the activation of certain genes, which may include Dbp5. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate may stimulate gene expression by inhibiting histone deacetylase, leading to increased histone acetylation and a subsequent increase in the accessibility of transcription factors to the DNA, possibly upregulating Dbp5. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol can stimulate gene transcription by binding estrogen receptors, which then dimerize and bind to estrogen response elements in the promoters of target genes, potentially upregulating Dbp5 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may increase the expression of certain genes by binding to glucocorticoid receptors, which then translocate to the nucleus and bind to glucocorticoid response elements, potentially including those near the Dbp5 gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can lead to increased expression of genes by inhibiting GSK-3, which normally phosphorylates transcription factors, thereby stabilizing them and allowing them to stimulate transcription, potentially including Dbp5. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin could induce gene expression by elevating intracellular calcium levels, which can activate calcium-dependent transcription factors and stimulate the transcription of genes, potentially Dbp5. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin could stimulate the expression of genes as a response to ER stress caused by the inhibition of N-linked glycosylation, activating the unfolded protein response, which may include upregulation of Dbp5. | ||||||