Dbf4b Inhibitors
Dbf4b Inhibitors are a class of chemical compounds that play a crucial role in regulating cellular processes and are primarily associated with the control of DNA replication in eukaryotic cells. The name "Dbf4b" stands for "Dumbbell Forming 4B," which is a protein involved in the initiation of DNA replication during the cell cycle. Inhibitors targeting Dbf4b are designed to interfere with its function, ultimately disrupting the DNA replication process. DNA replication is a fundamental process in cell division and growth, making Dbf4b Inhibitors of great interest in understanding the intricate molecular mechanisms underlying these vital cellular processes.
Dbf4b Inhibitors typically function by binding to the Dbf4b protein, preventing its interaction with other key proteins involved in DNA replication initiation. By doing so, they disrupt the formation of essential protein complexes required for DNA replication, effectively halting the replication process and causing cellular dysfunction. The inhibition of Dbf4b can have significant consequences for cell proliferation, as uncontrolled DNA replication is a hallmark of various diseases, including cancer. Therefore, understanding and developing compounds that target Dbf4b inhibitors can provide valuable insights into the regulation of DNA replication and may hold potential for future research in the context of cell cycle control and disease mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
A tetracyclic diterpene that specifically inhibits DNA polymerase α and δ, halting DNA replication. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
A purine derivative that inhibits CDKs, which can prevent the phosphorylation required for DNA replication initiation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A purine analog that inhibits CDKs, potentially disrupting the kinase activity necessary for DNA replication. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
A nucleoside that, when present in high concentrations, can lead to an imbalance in deoxynucleotide pools and inhibit DNA synthesis. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A synthetic flavonoid that inhibits CDKs, potentially affecting the phosphorylation cycle involved in DNA replication. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A derivative of staurosporine that selectively inhibits protein kinases, possibly affecting CDC7-DBF4's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A morpholine derivative that acts as a PI3K inhibitor, possibly affecting downstream elements involved in cell cycle regulation and DNA replication. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A steroidal metabolite that inhibits PI3K, which could alter the cell cycle and indirectly affect DNA replication. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
An agent that inhibits ribonucleotide reductase, leading to decreased deoxyribonucleotide levels and DNA synthesis inhibition. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase, disrupting DNA synthesis. | ||||||