D55 Inhibitors

Staurosporine and Genistein are kinase inhibitors that prevent the phosphorylation of proteins, a post-translational modification that often regulates protein activity. Rapamycin and LY294002 specifically target components of the PI3K/AKT/mTOR pathway, a key signaling axis that controls cell growth and survival, and thus could affect proteins regulated by this pathway. Further, PD98059 and SB203580 are selective inhibitors of the MAPK pathways, which are critical for cell proliferation, differentiation, and stress responses.

NF449 disrupts G-protein-coupled receptor signaling, while Cyclopamine antagonizes the Hedgehog pathway, both of which are integral to numerous cellular processes. ZM 447439 impedes the action of Aurora kinases, which are essential for cell division, and could affect proteins associated with the cell cycle. U73122 inhibits phospholipase C, influencing downstream signaling molecules and potentially altering proteins that depend on calcium signaling. Proteasome inhibitor Bortezomib is known to increase the levels of many proteins by preventing their degradation, which could change the abundance and activity of various proteins, including D55. Thapsigargin disrupts calcium stores by inhibiting the SERCA pump, potentially affecting calcium-dependent proteins.