D230039L06Rik Inhibitors

Kif26b, a member of the kinesin family, is predicted to play a crucial role in microtubule binding and motor activities. It is associated with cellular processes such as the establishment of cell polarity, positive regulation of cell-cell adhesion, and ureteric bud invasion, all of which are vital for normal cellular development and function. Located in the cytoplasm and cytoskeleton, Kif26b is expressed in various structures, including the alimentary system, central nervous system, genitourinary system, hindlimb interdigital region, and sensory organs.

Inhibition of Kif26b involves targeting its predicted microtubule-related functions. Chemicals like Nocodazole, Colchicine, Paclitaxel, Vinblastine, Griseofulvin, Vincristine, Vinorelbine, Epothilone B, Thiabendazole, Vinflunine, Podophyllotoxin, and Combretastatin A4 act either directly or indirectly on microtubule dynamics, influencing Kif26b's role in cellular processes. For instance, destabilizing agents like Nocodazole and Vinblastine disrupt microtubule structure, potentially impacting Kif26b's involvement in the establishment of cell polarity and cell-cell adhesion. Stabilizing agents like Paclitaxel and Epothilone B alter microtubule stability, potentially influencing Kif26b's role in the same processes. The diverse mechanisms of inhibition highlight the importance of microtubule dynamics in regulating Kif26b's functions and provide insights into potential strategies for modulating its activity in cellular contexts.