D14Ertd500e Inhibitors
Chemical inhibitors of D14Ertd500e act primarily by disrupting the normal polymerization and depolymerization dynamics of microtubules, which are critical components of the cell's cytoskeleton and essential for various cellular processes including cell division. Paclitaxel and Taxol, for instance, stabilize microtubules and prevent their disassembly, consequently inhibiting the cell cycle at stages where D14Ertd500e is active. This stabilization halts the dynamic changes required for the mitotic spindle to function correctly, thus indirectly inhibiting the function of D14Ertd500e. Similarly, Peloruside A also stabilizes microtubules, which would lead to a halt in cell division processes involving D14Ertd500e. On the other side of the spectrum, Podophyllotoxin, Colchicine, Vinblastine, and Vincristine disrupt microtubule assembly. Colchicine, for example, binds to tubulin to prevent its polymerization, and Vinblastine interferes with tubulin assembly into microtubules, thereby directly preventing the mitotic spindle formation that is a pre-requisite for the proper function of D14Ertd500e.
Further disrupting the function of D14Ertd500e, Nocodazole and Eribulin alter microtubule dynamics by inhibiting their polymerization and growth phase, respectively. Nocodazole effectively disrupts the mitotic spindle formation, which is crucial for D14Ertd500e's role in cell cycle regulation. Eribulin leads to mitotic block by specifically inhibiting the growth phase of microtubules without affecting their shortening, which is a unique mechanism among microtubule-targeting agents. Additionally, Monastrol and the related compounds S-Trityl-L-cysteine and Dimethylenastron target the mitotic kinesin Eg5, an enzyme that is essential for the separation of spindle poles during cell division. By inhibiting Eg5, these compounds induce the formation of monopolar spindles or prevent the formation of bipolar spindles, respectively, disrupting the mitotic apparatus and indirectly inhibiting the activity of D14Ertd500e in the process. Through these mechanisms, the chemical inhibitors exert their effects on the cellular level by targeting the structures and processes that are essential for D14Ertd500e to carry out its function in cell division.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is essential for mitotic spindle formation and cell division. As D14Ertd500e is involved in cell cycle progression, stabilization of microtubules by Paclitaxel would inhibit cell division, indirectly inhibiting the function of D14Ertd500e by preventing it from fulfilling its role in the cell cycle. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits the assembly of microtubules. Since D14Ertd500e functions are likely related to cell division and spindle assembly checkpoint, the disruption of microtubule dynamics by Podophyllotoxin would inhibit the proper function of D14Ertd500e in cell cycle control. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules. The inhibition of microtubule polymerization would disrupt mitotic spindle formation, thus inhibiting the cellular processes in which D14Ertd500e is involved, specifically those related to the cell cycle and mitosis. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine interferes with microtubule formation by binding to tubulin, which can inhibit cell division. Since D14Ertd500e is associated with cell cycle regulation, the disruption of microtubules by Vinblastine would inhibit the function of D14Ertd500e during mitosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which is critical for mitotic spindle formation. This disruption would inhibit the function of D14Ertd500e in cell cycle regulation and checkpoint control mechanisms. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to mitotic block. This specific action on microtubule dynamics would inhibit the function of D14Ertd500e in regulating cell cycle and mitosis. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a small molecule inhibitor of the kinesin Eg5 which is essential for spindle bipolarity. Inhibition of Eg5 by Monastrol leads to monopolar spindle formation, indirectly inhibiting the function of D14Ertd500e by disrupting the mitotic spindle apparatus where D14Ertd500e plays a role. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5, a kinesin-related motor protein that is essential for spindle pole separation. By inhibiting Eg5, it disrupts mitotic spindle formation, thereby inhibiting the function of D14Ertd500e in cell division. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is an inhibitor of the mitotic kinesin Eg5, which is important for the formation of bipolar spindles. Inhibition of Eg5 by Dimethylenastron would result in the disruption of mitotic spindle formation, thereby inhibiting the function of D14Ertd500e involved in mitosis. | ||||||