Cyp2c65 Activators
Cyp2c65, a cytochrome P450 enzyme, possesses diverse functions, including caffeine oxidase, heme binding, and monooxygenase activities. Involved in the epoxygenase P450 pathway and xenobiotic metabolism, Cyp2c65 plays a crucial role in drug metabolism and detoxification. Located in the cytoplasm and intracellular membrane-bounded organelles, Cyp2c65 has been implicated in various diseases, such as Plasmodium falciparum malaria, end-stage renal disease, eosinophilic esophagitis, invasive aspergillosis, and multiple chemical sensitivity. As an ortholog of CYP2C19, Cyp2c65 is part of the cytochrome P450 family.
Activation of Cyp2c65 involves direct and indirect mechanisms mediated by a variety of chemicals. Direct activators include Phenobarbital, Phenytoin, Ondansetron, and Carbamazepine, which upregulate Cyp2c65 expression and enhance its caffeine oxidase and monooxygenase activities. Indirect activators, such as St. John's Wort, Resveratrol, and Curcumin, modulate signaling pathways like AhR and Nrf2, influencing Cyp2c65 expression and activity. The overall mechanisms of activation revolve around the modulation of Cyp2c65 expression and function through cytochrome P450 and various cellular pathways, contributing to its crucial role in xenobiotic metabolism and detoxification. Understanding these activators provides insights into potential strategies for manipulating Cyp2c65 activity in the context of drug metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
5,5-Diphenyl Hydantoin, an antiepileptic drug, serves as a direct activator of Cyp2c65 by upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, indirectly activates Cyp2c65 by modulating the aryl hydrocarbon receptor (AhR) pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This affects xenobiotic metabolism and caffeine degradation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, serves as an indirect activator of Cyp2c65 by influencing the glucocorticoid receptor pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This modulates xenobiotic metabolism and caffeine degradation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound, indirectly activates Cyp2c65 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This influences xenobiotic metabolism and caffeine degradation. | ||||||
Ondansetron | 99614-02-5 | sc-201127 sc-201127A | 10 mg 50 mg | $82.00 $333.00 | 1 | |
Ondansetron, an antiemetic drug, serves as a direct activator of Cyp2c65 by upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
3-Methylcholanthrene, a polycyclic aromatic hydrocarbon, indirectly activates Cyp2c65 by influencing the aryl hydrocarbon receptor (AhR) pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This modulates xenobiotic metabolism and caffeine degradation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Niacinamide, a form of vitamin B3, indirectly activates Cyp2c65 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This influences xenobiotic metabolism and caffeine degradation. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine, an antiepileptic drug, serves as a direct activator of Cyp2c65 by upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, indirectly activates Cyp2c65 by modulating the aryl hydrocarbon receptor (AhR) pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This modulates xenobiotic metabolism and caffeine degradation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a natural compound, indirectly activates Cyp2c65 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c65, enhancing caffeine oxidase and monooxygenase activities. This influences xenobiotic metabolism and caffeine degradation. | ||||||