CYP11B1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metyrapone | 54-36-4 | sc-200597 sc-200597A sc-200597B | 200 mg 500 mg 1 g | $25.00 $56.00 $86.00 | 4 | |
Metyrapone acts as a selective inhibitor of CYP11B1, engaging in unique molecular interactions that disrupt steroidogenesis. Its structure allows for competitive binding at the enzyme's active site, altering the kinetics of cortisol synthesis. This inhibition can lead to a cascade of metabolic effects, as the compound modulates the enzymatic pathway involved in adrenal hormone production. Furthermore, its lipophilic nature may influence membrane interactions, potentially affecting enzyme accessibility and function. | ||||||
Etomidate | 33125-97-2 | sc-203577 | 10 mg | $124.00 | ||
Etomidate acts as a direct inhibitor of CYP11B1 by binding to its heme group and inhibiting the enzyme's activity in the conversion of 11-deoxycortisol to cortisol. This interference disrupts the adrenal steroidogenesis pathway, leading to decreased cortisol production. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole serves as a direct inhibitor of CYP11B1 by binding to the heme group of the enzyme. By doing so, it impedes the conversion of 11-deoxycortisol to cortisol, disrupting the adrenal steroidogenesis pathway and leading to decreased cortisol synthesis. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $41.00 $143.00 $530.00 $2020.00 | 2 | |
Aminoglutethimide acts as a direct inhibitor of CYP11B1 by targeting the enzyme's heme group. This inhibition disrupts the conversion of 11-deoxycortisol to cortisol, leading to decreased cortisol synthesis and impacting the adrenal steroidogenesis pathway. | ||||||
Trilostane | 13647-35-3 | sc-208469 sc-208469A | 10 mg 100 mg | $224.00 $1193.00 | 2 | |
Trilostane serves as a direct inhibitor of CYP11B1 by targeting the enzyme's heme group. This inhibition disrupts the conversion of 11-deoxycortisol to cortisol, impacting the adrenal steroidogenesis pathway and leading to decreased cortisol synthesis. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $71.00 $163.00 | 1 | |
Mitotane acts as a direct inhibitor of CYP11B1 by binding to the heme group of the enzyme. This interference disrupts the conversion of 11-deoxycortisol to cortisol, impacting the adrenal steroidogenesis pathway and leading to decreased cortisol production. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $114.00 $225.00 | 12 | |
Gossypol serves as an indirect inhibitor of CYP11B1 by modulating the expression of steroidogenic genes. By influencing the expression of key genes in the adrenal steroidogenesis pathway, gossypol disrupts cortisol synthesis and impacts CYP11B1-mediated steroidogenesis. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol indirectly inhibits CYP11B1 by affecting steroidogenic gene expression. Through modulation of key genes in the adrenal steroidogenesis pathway, this compound disrupts cortisol synthesis, impacting CYP11B1-mediated steroidogenesis. | ||||||
Diclofenac Sodium | 15307-79-6 | sc-202136 sc-202136A | 5 g 25 g | $40.00 $125.00 | 4 | |
Diclofenac serves as an indirect inhibitor of CYP11B1 by influencing the cytochrome P450 system. By affecting various cytochrome P450 enzymes, including CYP11B1, it disrupts the adrenal steroidogenesis pathway, leading to decreased cortisol synthesis. | ||||||
Sulfaphenazole | 526-08-9 | sc-215926 | 1 g | $307.00 | 7 | |
Sulfaphenazole acts as an indirect inhibitor of CYP11B1 by affecting the cytochrome P450 system. By inhibiting various cytochrome P450 enzymes, including CYP11B1, it disrupts the adrenal steroidogenesis pathway, leading to decreased cortisol synthesis. | ||||||