CYFIP1 Activators
The chemical class of CYFIP1 activators would encompass a range of molecules that can indirectly influence the activity of CYFIP1 by modulating various signaling pathways and cellular processes. These compounds would likely not bind directly to CYFIP1 but instead exert their effects by altering the cellular context in which CYFIP1 operates. The function of CYFIP1 is closely linked to the WAVE regulatory complex and actin cytoskeleton dynamics, thus compounds affecting these areas, like those interfering with mTOR signaling or actin polymerization, may inadvertently impact CYFIP1 activity.
Specifically, the functional mechanism by which these compounds may act includes altering the synthesis of proteins, modifying the organization of the cytoskeleton, or changing the phosphorylation state of proteins within signaling pathways that interface with CYFIP1 function. For instance, modulation of mTOR activity by compounds like rapamycin would affect protein synthesis rates and could thereby influence the assembly or function of protein complexes involving CYFIP1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Phalloidin binds and stabilizes actin filaments, potentially altering cytoskeletal dynamics. Since CYFIP1 is part of the WAVE regulatory complex that controls actin polymerization, stabilizing actin filaments may indirectly influence CYFIP1 activity by altering the cellular context in which it operates, potentially leading to changes in its regulatory functions. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can lead to the formation of actin aggregates. This compound's impact on the actin cytoskeleton could indirectly affect CYFIP1's interactions with the actin network, possibly modulating its activity as a result of changes in actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization. Disrupting actin polymerization could release CYFIP1 from actin-bound states, potentially modifying its activity within the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and potentially activating PKA. PKA can phosphorylate various proteins, which could lead to a cascade of events affecting the function or localization of CYFIP1 indirectly. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), leading to increased cAMP levels in the cell. This elevation in cAMP could indirectly influence pathways that modulate the activity or expression of CYFIP1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that potentially affects actin organization by inhibiting the phosphorylation of myosin light chains. Since actin dynamics are linked to CYFIP1 function, this could indirectly influence CYFIP1 activity. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, affecting muscle contraction and cell motility. As a regulator of actin dynamics, CYFIP1 may be indirectly affected by changes in myosin II activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Although typically associated with cell growth and proliferation, the MAPK pathway intersects with many signaling networks, possibly influencing CYFIP1 activity indirectly. | ||||||