cyclin M3 Activators
Cyclin M3 Activators encompass a group of chemical compounds that influence various signaling pathways to enhance the functional activity of cyclin M3, a protein involved in cell cycle regulation. Forskolin, by raising cAMP levels, and Phorbol 12-myristate 13-acetate (PMA), as an activator of PKC, both contribute to cell cycle progression, potentially augmenting the role ofcyclin M3. Epigallocatechin gallate (EGCG) and Staurosporine, though generally acting as kinase inhibitors, may selectively improve cyclin M3's contributions to cell cycle control by inhibiting negative regulatory elements. PI3K inhibitors like LY294002 and Wortmannin, along with MEK inhibitors such as U0126 and PD 98059, downregulate pathways that, when inhibited, can lead to a relative increase in cyclin M3 activity.
The modulation of calcium levels by compounds such as Thapsigargin and A23187 can activate calcium-dependent kinases that favor cyclin M3's role in the cell cycle. Additionally, bioactive lipids like Sphingosine-1-phosphate can initiate signaling conducive to cyclin M3's function in cell cycle transitions. SB203580's inhibition of p38 MAPK also supports the activity of cyclin M3 in cell cycle regulation. The collective effects of these activators can enhance the progression through various phases of the cell cycle, particularly the G1/S and G2/M checkpoints, where cyclin M3 is pivotal.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate targets including transcription factors that may enhance the expression and activity of cyclin M3 in the cell cycle regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation leads to altered cell cycle progression and can enhance the activity of cyclin M3 by promoting its role in the regulation of the G2/M transition in the cell cycle. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a known inhibitor of several protein kinases. Inhibition of these kinases can result in the upregulation of cyclin M3 activity, as it removes negative regulatory influences on the cell cycle, allowing cyclin M3 to more effectively promote cell cycle progression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it reduces AKT phosphorylation and activity, which can lead to an upregulation of cyclin-dependent kinase activities, including those involving cyclin M3, thus enhancing its function in cell cycle regulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that operates similarly to LY294002. It can enhance cyclin M3 activity by preventing the phosphorylation and inactivation of cell cycle regulators that work in conjunction with cyclin M3 to control cell proliferation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. The inhibition of p38 MAPK can lead to the enhancement of cyclin M3 activity by favoring cell cycle progression through the G2/M checkpoint, where cyclin M3 is known to play a critical role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that can activate signaling pathways involved in cell cycle progression. It may enhance cyclin M3 activity by promoting the transition through G1/S and G2/M phases of the cell cycle, where cyclin M3 is involved. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. While it generally inhibits kinases, it may lead to selective enhancement of cyclin M3 by reducing the activity of kinases that negatively regulate the cell cycle, thus indirectly promoting the function of cyclin M3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, which reduces ERK pathway signaling. By inhibiting this pathway, PD 98059 can indirectly enhance the activity of cyclin M3 by preventing the phosphorylation of negative regulators of the cell cycle, and thereby support the role of cyclin M3 in cell division. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium can lead to the activation of calcium-dependent signaling pathways that enhance the activity of cyclin M3 by promoting cell cycle progression through phases where cyclin M3 is critical. | ||||||