Cyclin D1 Activators
Cyclin D1 activators are a group of molecules that play a pivotal role in the regulation of the cell cycle, particularly in the G1 phase, which is the initial stage of cell division. These activators are involved in controlling the progression of cells from a quiescent state (G0) into the active phase of the cell cycle, allowing them to prepare for DNA replication and ultimately cell division. Cyclin D1 activators function by promoting the activation of cyclin-dependent kinases (CDKs), specifically CDK4 and CDK6, through binding and phosphorylation events. At the molecular level, cyclin D1 activators are often associated with the D-type cyclins, particularly cyclin D1, which forms complexes with CDK4 or CDK6. These complexes, when properly activated, act as molecular switches, leading to the phosphorylation of key substrates involved in cell cycle progression. This phosphorylation cascade subsequently leads to the release of transcription factors like E2F, which promote the expression of genes necessary for cell cycle progression and DNA synthesis.
Cyclin D1 activators are regulated tightly, and their dysregulation can lead to uncontrolled cell proliferation, a hallmark of cancer. In summary, cyclin D1 activators are essential players in the intricate machinery that governs the cell cycle. Their role in promoting the transition from the G0 phase to the active cell cycle phases is fundamental to the proper functioning of cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural compound found in grapes, red wine, and certain plants. It activates Cyclin D1 by modulating various signaling pathways, including the PI3K/AKT and Wnt pathways. It promotes cell cycle progression and has been studied for its potential anticancer effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a polyphenol found in turmeric. It activates Cyclin D1 by inhibiting various transcription factors, such as NF-κB, that are involved in cell cycle regulation. Curcumin has been shown to have anti-inflammatory and anticancer properties. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea. It activates Cyclin D1 by inhibiting the activity of cyclin-dependent kinase (CDK) inhibitors, such as p21 and p27. EGCG's anticancer potential has been extensively studied. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid present in various fruits and vegetables. It activates Cyclin D1 by modulating multiple signaling pathways, including the JAK/STAT pathway. Quercetin's antioxidant and anti-inflammatory properties are well-documented. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables like broccoli. It activates Cyclin D1 by affecting the MAPK/ERK pathway and promoting cell cycle progression. Sulforaphane is known for its potential as a cancer chemopreventive agent. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a derivative of vitamin A. It activates Cyclin D1 by binding to retinoic acid receptors (RARs) and regulating the transcription of target genes involved in cell cycle control. It is used in cancer therapy and skin health. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soy products. It activates Cyclin D1 by inhibiting protein tyrosine kinases and affecting cell signaling pathways. Genistein is under investigation for its potential in cancer prevention. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
Indirubin-3'-monoxime is a synthetic derivative of indirubin, a component of traditional Chinese medicine. It activates Cyclin D1 by inhibiting CDKs and promoting cell cycle progression. It has been studied for its potential as an anticancer agent. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin is a flavonoid found in citrus fruits. It activates Cyclin D1 by modulating various signaling pathways, including the PI3K/AKT pathway. Naringenin has antioxidant and anti-inflammatory properties. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $46.00 $130.00 | 21 | |
Thymoquinone is a component of black cumin seeds. It activates Cyclin D1 by regulating the expression of cell cycle-related genes. It is being investigated for its potential in cancer therapy and as an antioxidant. | ||||||