CTU2 Activators
The category of CTU2 Activators comprises a range of chemicals that can modulate the function of the CTU2 protein by influencing related signaling pathways or cellular processes. These chemicals primarily operate through two main mechanisms. The first group of activators, including Forskolin, Isoproterenol, IBMX, and Rolipram, functions by increasing the intracellular levels of cyclic AMP (cAMP), which activates Protein Kinase A (PKA). PKA then phosphorylates and activates CTU2. Also included in this category are Bt2cAMP, a direct activator of PKA, and chemicals such as Regorafenib and Staurosporine, which act by inhibiting kinases that negatively regulate the cAMP-PKA signaling pathway, facilitating CTU2 activation.
The second group of activators in this category, including Okadaic acid and Calyculin A, operates by inhibiting protein phosphatases PP1 and PP2A, which are responsible for removing phosphate groups from proteins. By inhibiting these phosphatases, these chemicals increase the overall phosphorylation state of proteins, which can lead to CTU2 activation. LY294002, a PI3K inhibitor, and U0126, a MEK1/2 inhibitor, can also increase cAMP levels indirectly by inhibiting pathways that negatively regulate cAMP-PKA signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which elevates cellular levels of cyclic AMP (cAMP). The increased cAMP levels can activate PKA, a kinase that can phosphorylate and activate CTU2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that stimulates adenylate cyclase, leading to a rise in cAMP and subsequent PKA activation. This sequence of events can result in the phosphorylation and activation of CTU2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, enzymes that degrade cAMP. By inhibiting these enzymes, IBMX increases cAMP levels, which can activate PKA and result in CTU2 phosphorylation and activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective PDE4 inhibitor. By inhibiting PDE4, Rolipram increases cAMP levels, which can trigger PKA activation and lead to CTU2 phosphorylation and activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Bt2cAMP is a membrane-permeable cAMP analog that can activate PKA directly. This PKA activation can lead to the phosphorylation and activation of CTU2. | ||||||
Regorafenib | 755037-03-7 | sc-477163 sc-477163A | 25 mg 50 mg | $320.00 $430.00 | 3 | |
Regorafenib is a multi-kinase inhibitor that can indirectly activate CTU2 by inhibiting kinases that negatively regulate cAMP-PKA signaling, thus promoting CTU2 activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. It can indirectly increase cAMP levels by inhibiting the PI3K-Akt pathway, a negative regulator of cAMP-PKA signaling, leading to PKA activation and subsequent CTU2 phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, okadaic acid can increase the phosphorylation state of proteins, including CTU2. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it can increase the phosphorylation state of proteins, potentially activating CTU2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can indirectly activate CTU2 by inhibiting kinases that negatively regulate cAMP-PKA signaling. | ||||||