Date published: 2025-10-11

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CTH Inhibitors

CTH inhibitors belong to a specific category of compounds that are designed to interact with and modulate the function of the cystathionine gamma-lyase (CTH) enzyme. CTH is an enzyme that plays a crucial role in the transsulfuration pathway of sulfur amino acid metabolism. This metabolic pathway is intricately involved in the biosynthesis of cysteine, an essential amino acid that has numerous roles in cellular processes, including protein synthesis and the formation of crucial signaling molecules.The function of CTH inhibitors revolves around their ability to bind to the active sites or binding domains of the CTH enzyme, thereby influencing its enzymatic activity. By altering the function of CTH, these inhibitors offer a means to investigate the intricate regulatory mechanisms that govern sulfur amino acid metabolism and its impact on cellular homeostasis. The study of CTH inhibitors provides valuable insights into the complex interplay between various metabolic pathways and their implications for cellular function. As the transsulfuration pathway is interconnected with other metabolic networks, the exploration of CTH inhibitors can unravel the broader metabolic connections and contribute to our understanding of how cells maintain their equilibrium in response to changing conditions.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-2,3-Diaminopropionic acid hydrochloride

1482-97-9sc-255233
1 g
$209.00
(0)

L-2,3-Diaminopropionic acid hydrochloride functions as a versatile acid halide, exhibiting strong electrophilic characteristics that facilitate rapid nucleophilic attacks. Its dual amine groups enhance its reactivity, enabling the formation of stable intermediates in condensation reactions. The compound's unique steric configuration allows for selective interactions with various nucleophiles, promoting distinct pathways in synthetic chemistry. Additionally, its solubility in polar solvents enhances its accessibility in diverse reaction conditions.

DL-Propargylglycine

64165-64-6sc-294408
sc-294408A
1 g
5 g
$169.00
$678.00
(0)

PAG is a classic inhibitor of CTH that binds to the active site of the enzyme, preventing its catalytic activity and H2S production.

β-cyano-L-Alanine

6232-19-5sc-205546
sc-205546A
10 mg
50 mg
$14.00
$47.00
(0)

β-Cyano-L-Alanine serves as a notable acid halide, characterized by its unique ability to engage in diverse nucleophilic substitution reactions. The presence of the cyano group introduces significant electron-withdrawing effects, which enhance the electrophilicity of the carbonyl carbon. This compound exhibits distinct reaction kinetics, often leading to rapid formation of adducts. Its polar nature and ability to form hydrogen bonds facilitate interactions with a variety of reagents, promoting unique synthetic pathways.

DL-Propargylglycine (hydrochloride)

16900-57-5sc-221558
sc-221558A
sc-221558B
sc-221558C
1 mg
5 mg
10 mg
50 mg
$24.00
$108.00
$144.00
$630.00
(0)

DL-Propargylglycine (hydrochloride) is a distinctive compound that acts as a CTH, showcasing unique reactivity due to its propargyl group. This alkyne moiety allows for selective participation in cycloaddition reactions, enhancing its utility in synthetic chemistry. The presence of the hydrochloride form increases solubility and stability, promoting efficient interactions with nucleophiles. Its ability to form stable intermediates contributes to diverse reaction pathways, making it a versatile building block in organic synthesis.

Bicinchoninic acid disodium salt

979-88-4sc-278767
sc-278767A
sc-278767C
sc-278767B
1 g
50 g
250 g
500 g
$102.00
$265.00
$979.00
$2968.00
3
(0)

BCA is a reversible inhibitor of CTH, potentially affecting H2S production by interfering with its enzymatic activity.

Hydroxylamine solution

7803-49-8sc-250136
100 ml
$71.00
(0)

Hydroxylamine might inhibit CTH by interacting with its active site, interfering with enzymatic activity and H2S production.

Oxamic acid

471-47-6sc-250620
25 g
$145.00
(0)

Oxamic acid is a reversible inhibitor that might interfere with CTH's enzymatic activity and impact H2S production.

Homocysteine

6027-13-0sc-507315
250 mg
$195.00
(0)

L-Homocysteine might inhibit CTH by competing with its substrate, L-cystathionine, and impacting H2S production.

L-Methionine

63-68-3sc-394076
sc-394076A
sc-394076B
sc-394076C
sc-394076D
sc-394076E
25 g
100 g
250 g
1 kg
5 kg
10 kg
$33.00
$36.00
$56.00
$148.00
$566.00
$1081.00
(0)

L-Methionine might indirectly affect CTH activity by providing a substrate for the transsulfuration pathway, influencing H2S production.

L-Cysteine

52-90-4sc-286072
sc-286072A
sc-286072B
sc-286072C
sc-286072D
25 g
100 g
500 g
5 kg
10 kg
$50.00
$110.00
$440.00
$1128.00
$2135.00
1
(1)

L-Cysteine might influence CTH activity and H2S production through its role as a precursor in the H2S synthesis pathway.