beta-cyano-L-Alanine CAS: 6232-19-5
MF: C4H6N2O2
MW: 114.1
A reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase.

β-cyano-L-Alanine (CAS 6232-19-5)

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备用名: BCA
应用; β-cyano-L-Alanine is a reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase
CAS号码: 6232-19-5
分子量: 114.1
分子式: C4H6N2O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CTH (CSE). BCA blocks H2S synthesis activity in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats. Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, CTH (cystathionine γ lyase CSE) and cystathionineβ synthetase (CBS).


参考文献

1 Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007). 2 Wang, R. Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter?. FASEB J 16(13) 1792-1798 (2002). 3 Pfeffer, M., Ressler, C. b-cyanoalanine, an inhibitor of rat liver cystathionase. Biochem Pharmacol 16 2299-2308 (1967). 4 Mok, Y.P., Atan, M.S.B.M., Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 143 881-889 (2004). 5 Kawabata, A., Ishiki, T., Nagasawa, K., et al. Hydrogen sulfide as a novel nociceptive messenger. Pain 132 74-81 (2008).

物理状态 :
Solid
溶解度 :
Soluble in water (10 mg/ml), ethanol, DMSO, DMF, and PBS (pH 7.2) (~10 mg/ml).
保存 :
Store at -20° C
熔点 :
217° C
沸点 :
~368.1° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.50 (Predicted)
IC50 :
Blocks H2S synthesis: IC50 = 6.5 µM (rat liver preparations)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
MDL 号码 :
MFCD00021722
SMILES :
C(C#N)[[email protected]@H](C(=O)O)N

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