CTH Activators
Common CTH Activators include, but are not limited to N-Acetyl-L-cysteine CAS 616-91-1, Resveratrol CAS 501-36-0, Curcumin CAS 458-37-7, (+)-α-Tocopherol CAS 59-02-9 and L-Ascorbic acid, free acid CAS 50-81-7.
Cystathionine gamma-lyase (CTH) is an enzyme vital for the transsulfuration pathway, a process essential for the synthesis of the amino acid cysteine from methionine in mammals. CTH catalyzes several reactions that involve the breakdown of cystathionine to form cysteine, alpha-ketobutyrate, and ammonia. Moreover, CTH plays a pivotal role in the endogenous production of hydrogen sulfide (H2S), a gaseous signaling molecule involved in various physiological processes, including vasodilation, neuromodulation, and cellular protection mechanisms. The precise regulation of CTH is imperative for maintaining the intricate balance of sulfur-containing amino acids within the body and the associated metabolic pathways.
CTH Activators refer to a category of molecules designed to boost or enhance the activity of the Cystathionine gamma-lyase enzyme. By promoting the enzymatic function of CTH, these activators would facilitate the efficient synthesis of cysteine from cystathionine and bolster the endogenous production of H2S. An augmented activity of CTH might have implications in the regulation of sulfur amino acid metabolism, influencing the redox state, cellular antioxidant capacities, and the overall sulfur balance within the organism. Given the crucial role of H2S in various cellular activities, CTH activators could indirectly modulate a myriad of physiological processes by influencing H2S levels. The exploration and understanding of CTH activators offer a promising avenue to delve deeper into the intricacies of sulfur amino acid metabolism and the vast implications of H2S in cellular and systemic physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As a precursor of cysteine, NAC might upregulate CTH expression to increase cysteine availability for glutathione synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known for its antioxidant properties, resveratrol might enhance CTH expression as part of a broader cellular response to oxidative stress. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
With its anti-inflammatory and antioxidant properties, curcumin might influence the transsulfuration pathway and upregulate CTH. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Ademetionine is involved in methionine metabolism and might influence the balance of homocysteine, potentially impacting CTH expression. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
As an antioxidant, Vitamin E might modulate oxidative stress responses, potentially influencing CTH expression. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Another key antioxidant, Vitamin C might influence pathways related to oxidative stress and potentially upregulate CTH expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As a reactive oxygen species, hydrogen peroxide might upregulate CTH as a compensatory mechanism to boost glutathione synthesis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As a cofactor for various enzymes, zinc might influence CTH expression directly or through its antioxidant properties. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane can activate the Nrf2 pathway, which might upregulate antioxidant proteins, including CTH. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Known for its antioxidant properties, it might modulate the cellular redox state and potentially upregulate CTH expression. | ||||||