CROP Inhibitors
Chemical inhibitors of CROP play a pivotal role in modulating RNA splicing by interfering with various stages of the spliceosome assembly and function. Staurosporine, a kinase inhibitor, can inhibit CROP by preventing the phosphorylation of proteins involved in splicing, thereby altering their activity and potentially their interaction with RNA. Similarly, H-89, as an inhibitor of protein kinase A, can lessen the phosphorylation of spliceosome components, which might be necessary for CROP to exert its function in RNA splicing. DRB interferes with RNA Polymerase II activity, which, beyond its role in transcription, also phosphorylates proteins that are part of the splicing machinery; this can indirectly affect CROP's function. Another compound, 5-Iodotubercidin, inhibits adenosine kinase, which can disrupt ATP-dependent splicing events where CROP is involved, given the necessity of ATP in the splicing process.
Further influencing the splicing process are compounds that target the spliceosome directly. Pladienolide B and Madrasin specifically inhibit the SF3b complex, a crucial component of the spliceosome, which can disrupt the proper assembly and function of the spliceosome itself, indirectly inhibiting CROP's role. Meayamycin, targeting the core spliceosome B complex, can inhibit the assembly or activity of the spliceosome, thereby affecting CROP's functionality. Isoginkgetin interrupts pre-mRNA splicing by preventing spliceosome assembly, which can lead to an inhibition of CROP's activity in splicing. Eupolauridine and Toyocamycin can interfere with RNA polymerase I and ATP-dependent RNA processing events, respectively, which can indirectly inhibit the function of CROP in RNA splicing. Lastly, Herboxidiene can inhibit the splicing of a subset of pre-mRNAs, thereby having an indirect effect on CROP's function within the splicing process. These chemical inhibitors, by targeting various components and stages of the splicing cycle, can effectively modulate the activity of CROP in RNA splicing.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. CROP is implicated in RNA splicing, and phosphorylation status can influence splicing factors and their interaction with RNA. Staurosporine inhibits kinases that could phosphorylate splicing factors, potentially leading to an inhibition of CROP's role in RNA splicing. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
5-Iodotubercidin is an adenosine kinase inhibitor. Adenosine kinases can influence RNA processing and splicing through ATP-dependent mechanisms. By inhibiting adenosine kinases, 5-Iodotubercidin may disrupt ATP-dependent splicing reactions where CROP is involved, leading to a functional inhibition of CROP's role in splicing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB, or 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole, is an adenosine analog that inhibits RNA Polymerase II. Although it primarily affects transcription, RNA Polymerase II also phosphorylates the C-terminal domain of RNA splicing factors. By inhibiting this phosphorylation, DRB could indirectly inhibit CROP's splicing activity. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Pladienolide B is a spliceosome inhibitor which targets the SF3b complex. Since CROP is associated with RNA splicing, inhibitors of the spliceosome machinery can indirectly inhibit CROP's function by disrupting the proper assembly and function of the spliceosome, of which CROP is a component. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a pre-mRNA splicing inhibitor. It disrupts the splicing of pre-mRNA by preventing spliceosome assembly. Since CROP is involved in RNA splicing, the inhibition of spliceosome assembly by Isoginkgetin can indirectly lead to a functional inhibition of CROP's splicing activity. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
Madrasin is a specific inhibitor of the spliceosome's SF3b complex. By inhibiting this complex, Madrasin interferes with the spliceosome assembly and function. Since CROP operates within the spliceosome, the inhibition of SF3b by Madrasin can indirectly inhibit the splicing functions of CROP. | ||||||
Toyocamycin | 606-58-6 | sc-362812 | 10 mg | $138.00 | ||
Toyocamycin is an adenosine analog that inhibits RNA function. It can bind to adenosine triphosphate (ATP) binding sites, affecting ATP-dependent RNA processing events. Since RNA splicing can be ATP-dependent, Toyocamycin's action can indirectly lead to an inhibition of CROP by disrupting ATP-dependent processes in which CROP is involved. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene, also known as GEX1A, is a natural product that specifically inhibits the splicing of a subset of pre-mRNAs. By disrupting the splicing process, Herboxidiene can indirectly inhibit CROP's function in RNA splicing as CROP is a component of the splicing machinery. | ||||||