CPSF1 Activators
CPSF1 Activators encompass a variety of chemical compounds that indirectly promote the functional activity of CPSF1 through diverse signaling mechanisms. Compounds such as Forskolin and 8-Br-cAMP act through elevating intracellular cAMP levels, leading to the activation of protein kinase A (PKA). This activation may result in the phosphorylation of CPSF1 or its associated factors, optimizing its functionality in the cleavage and polyadenylation specificity factor complex, which is crucial for the maturation of mRNA. Similarly, agents like Spermidine and ZnSO4 are thought to bolster CPSF1's activity by enhancing its RNA binding affinity or stability, which is fundamental for its role in mRNA processing. Amiloride, by indirectly raising intracellular calcium levels, and Ionomycin, through its action as a calcium ionophore, can activate calcium-dependent signaling pathways that might positively influence the activity of CPSF1 in mRNA 3' end processing. Caffeine and Rolipram, by inhibiting phosphodiesterases, result in the accumulation of cAMP, which further supports the hypothesis of PKA-mediated enhancement of CPSF1 function. AICAR, an activator of AMPK, could also indirectly facilitate CPSF1 activity by initiating a cascade of phosphorylation events that modify the activity or interaction of CPSF1 with its substrate or other protein factors.
Moreover, CPSF1 activators include PMA, which is known to activate PKC. This activation might lead to secondary phosphorylation events that enhance the efficiency of CPSF1 in mRNA processing. IBMX and Zaprinast, both phosphodiesterase inhibitors, contribute to this collective mechanism by elevating cAMP and indirectly promoting PKA activity, which could translate into heightened CPSF1 functionality. Collectively, these compounds, through their targeted effects on cellular signaling, aid in the enhancement of CPSF1-mediated functions integral to mRNA maturation without increasing its expression or requiring direct activation. This intricate network of biochemical modulations ensures the fine-tuning of CPSF1 activity, which is pivotal in the post-transcriptional regulation of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which can activate PKA. PKA phosphorylation can lead to changes in the phosphorylation state of CPSF1, thus potentially enhancing its activity in the cleavage and polyadenylation specificity factor complex for mRNA processing. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate acts as a cAMP analog and activates PKA. This activation could phosphorylate proteins associated with CPSF1, optimizing its activity in mRNA maturation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate can stabilize RNA-binding proteins and potentially enhance the function of CPSF1 by improving its binding efficiency to pre-mRNA substrates, which is crucial for its role in 3' end processing of mRNA transcripts. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine facilitates RNA binding and can improve the efficiency of CPSF1 in the processing of pre-mRNA by enhancing its substrate binding affinity or altering its conformation for better functional performance. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride indirectly increases intracellular calcium levels, which may influence the function of CPSF1 by modulating the cleavage and polyadenylation of mRNA through calcium-dependent signaling pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, thereby increasing cAMP levels, which indirectly could lead to an enhanced activity of CPSF1 through the cAMP-PKA signaling axis and subsequent phosphorylation events. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels and PKA activation. This could enhance CPSF1 activity by promoting phosphorylation processes that influence its function in mRNA processing. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can lead to phosphorylation of downstream targets that may interact with or modulate the activity of CPSF1, potentially optimizing its role in mRNA cleavage and polyadenylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate activates PKC, which might indirectly lead to phosphorylation and activation of proteins that regulate CPSF1 activity, thereby enhancing its role in the mRNA maturation process. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate signaling pathways that may modulate CPSF1 function, leading to improved efficiency in its role in mRNA 3' end processing. | ||||||