COX4 Activators

Common COX4 Activators include, but are not limited to Resveratrol CAS 501-36-0, AICAR CAS 2627-69-2, Retinoic Acid, all trans CAS 302-79-4, Bezafibrate CAS 41859-67-0 and NAD+, Free Acid CAS 53-84-9.

COX4 activators belong to a class of compounds that interact with Cytochrome c Oxidase Subunit 4 (COX4), a crucial component of the electron transport chain (ETC) in mitochondria. The electron transport chain is a series of protein complexes and cytochromes located in the inner mitochondrial membrane, which plays a central role in oxidative phosphorylation, the primary process by which cells generate adenosine triphosphate (ATP), the cellular energy currency. COX4 is a subunit of cytochrome c oxidase (Complex IV), the terminal enzyme in the electron transport chain, which transfers electrons from cytochrome c to molecular oxygen, ultimately producing water and contributing to the generation of a proton gradient used to synthesize ATP.

COX4 activators are compounds designed to modulate the activity of COX4, with applications in understanding mitochondrial function, cellular bioenergetics, and metabolic pathways. By affecting COX4, these compounds can have a profound impact on cellular energy production and metabolism. The ability to activate or inhibit COX4 may provide insights into the regulation of oxidative phosphorylation, offering researchers valuable tools to investigate mitochondrial function in health and disease.