Cox-2 Inhibitors
Items 101 to 107 of 107 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
7-(Trifluoromethyl)1H-indole-2,3-dione | 391-12-8 | sc-217411 | 100 mg | $330.00 | ||
7-(Trifluoromethyl)1H-indole-2,3-dione exhibits a distinctive mechanism of action with COX-2 through its electron-withdrawing trifluoromethyl group, which enhances its electrophilicity. This compound can form stable adducts with key amino acid residues in the enzyme's active site, altering the enzyme's conformation and inhibiting its activity. Its unique structural arrangement promotes specific steric interactions, influencing reaction kinetics and selectivity in biochemical pathways. | ||||||
Ampiroxicam | 99464-64-9 | sc-210813 | 10 mg | $187.00 | ||
Ampiroxicam features a unique structural framework that allows for selective inhibition of COX-2 through its specific binding interactions. The compound's hydrophobic regions facilitate strong van der Waals forces with the enzyme's active site, promoting a conformational change that disrupts catalytic activity. Additionally, its ability to form hydrogen bonds with critical amino acid residues enhances binding affinity, influencing the overall kinetics of the enzymatic reaction and modulating inflammatory pathways. | ||||||
(S)-(+)-Ibuprofen (S)-(+)-Lysinate | sc-220042 | 25 mg | $320.00 | |||
(S)-(+)-Ibuprofen (S)-(+)-Lysinate exhibits a distinctive stereochemistry that enhances its interaction with the COX-2 enzyme. The compound's chiral center contributes to its selective binding, allowing for precise alignment within the active site. This alignment fosters unique electrostatic interactions, stabilizing the enzyme-substrate complex. Furthermore, its solubility characteristics promote efficient diffusion, influencing the rate of enzymatic inhibition and altering metabolic pathways. | ||||||
(S)-(+)-Ketoprofen | 22161-81-5 | sc-212844 | 100 mg | $166.00 | ||
(S)-(+)-Ketoprofen is characterized by its unique chiral configuration, which facilitates a specific orientation when interacting with the COX-2 enzyme. This stereochemical arrangement enhances its affinity for the enzyme's active site, leading to distinct hydrogen bonding and hydrophobic interactions that stabilize the complex. Additionally, its molecular structure influences reaction kinetics, allowing for a tailored modulation of inflammatory pathways, while its solubility properties affect bioavailability and distribution in biological systems. | ||||||
Firocoxib | 189954-96-9 | sc-470944 | 1 mg | $260.00 | ||
Firocoxib is a COX-2 inhibitor primarily used in veterinary medicine to manage pain and inflammation in animals. It targets COX-2 and limits prostaglandin production. | ||||||
Meloxicam-d3 | 942047-63-4 | sc-218687 | 1 mg | $367.00 | ||
Meloxicam-d3 exhibits a distinctive molecular architecture that enhances its selectivity for the COX-2 enzyme. Its deuterated form alters the vibrational frequencies of key functional groups, potentially influencing reaction kinetics and stability. The compound's unique interactions with the enzyme's active site involve specific hydrophobic pockets and electrostatic interactions, which may modulate the enzyme's conformation. This tailored interaction profile contributes to its distinct biochemical behavior. | ||||||
DFU | 178402-36-3 | sc-489951 | 5 mg | $61.00 | ||
DFU is characterized by its unique reactivity as an acid halide, facilitating selective acylation reactions. Its electrophilic carbonyl group engages in nucleophilic attack, leading to rapid formation of acyl derivatives. The presence of halogen atoms enhances its reactivity, promoting specific interactions with nucleophiles through polarizing effects. Additionally, DFU's steric properties influence substrate accessibility, allowing for tailored reaction pathways and distinct kinetic profiles in various chemical environments. | ||||||