connexin 23 Activators
Connexin 23 Activators are chemical compounds that can directly or indirectly enhance the functional activity of connexin 23. These activators operate by influencing specific signaling pathways or cellular processes that connexin 23 is directly involved in. For instance, compounds like Retinoic Acid, Phorbol 12-myristate 13-acetate (PMA), N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate (db-cAMP), Forskolin, 8-Bromo-cAMP, 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), and Isoproterenenol function by enhancing the phosphorylation of connexin 23, a key process necessary for its functional activation. These compounds exert their effects through the retinoic acid signaling pathway, Protein Kinase C (PKC), Protein Kinase A (PKA), and adenylyl cyclase respectively, which are known to phosphorylate connexin 23 and hence enhance its activity.
Other compounds such as Epigallocatechin gallate (EGCG) and Tetrodotoxin (TTX) indirectly contribute to the activation of connexin 23 by maintaining membrane depolarization, a necessary condition for the gating of connexin 23 channels. Sphingosine-1-phosphate (S1P) and Meclofenamic Acid, on the other hand, modulate the gating of connexin 23 channels and alter the intercellular communication environment respectively, leading to enhanced connexin 23 activity. Genistein plays a unique role as it inhibits protein tyrosine kinases, and in doing so, alters the phosphorylation status of connexin 23, thereby indirectly enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of vitamin A that plays a role in cell growth, differentiation, and development. It influences the phosphorylation of connexin 23, a process that is necessary for its functional activation, through the retinoic acid signaling pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is used as a research tool in cell biology. It activates Protein Kinase C (PKC), which can phosphorylate connexin 23, leading to its functional activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol present in green tea. It inhibits the activity of ATP-sensitive potassium channels, which can indirectly enhance the activity of connexin 23 by maintaining membrane depolarization, a condition necessary for the gating of connexin 23 channels. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog. It enhances the activity of Protein Kinase A (PKA), which can phosphorylate connexin 23, leading to its functional activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP). Increased cAMP levels can activate PKA, which phosphorylates connexin 23 and enhances its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable, phosphodiesterase-resistant analog of cAMP that activates PKA. PKA can phosphorylate connexin 23, leading to its functional activation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid mediator that regulates various physiological processes. It is known to affect the gating of connexin channels, and thus can enhance the activity of connexin 23. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $87.00 $316.00 | 19 | |
8-CPT-cAMP is a cell-permeable, phosphodiesterase-resistant cAMP analog. It activates PKA, which phosphorylates connexin 23, leading to its functional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavonoid found in soy products that inhibits protein tyrosine kinases. By doing so, it can alter phosphorylation status of connexin 23, leading to its functional activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases intracellular cAMP levels. The increased cAMP activates PKA, which phosphorylates connexin 23 and enhances its activity. | ||||||