COL4A1 Activators
The class of COL4A1 activators encompasses a diverse array of chemical compounds, each chosen for its unique mechanism of action with the ability to stimulate the activity of the collagen type IV alpha 1 chain (COL4A1). These compounds play a crucial role in influencing the maintenance of basement membranes, vital structures providing structural support and integrity to various tissues. One notable member of this class is Prostaglandin E2 (PGE2), a lipid mediator that activates EP receptors, particularly EP2 and EP4, leading to increased cAMP levels. PGE2's signaling through EP receptors directly modulates pathways related to collagen synthesis, influencing COL4A1 activity and contributing to the maintenance of basement membrane structure. Forskolin, an adenylate cyclase activator, is another key compound in this class. It elevates intracellular cAMP levels, activating protein kinase A (PKA). Forskolin's stimulation of cAMP/PKA signaling directly influences pathways related to collagen synthesis, impacting COL4A1 activity and the preservation of basement membrane integrity.
A23187, a calcium ionophore, facilitates calcium influx into cells, leading to increased intracellular calcium levels. This activation of calcium signaling directly influences pathways related to collagen synthesis, thereby affecting COL4A1 activity and the maintenance of basement membrane integrity. Iloprost, a prostacyclin analog, activates prostacyclin receptors, resulting in increased cAMP levels. Iloprost's signaling through prostacyclin receptors directly modulates pathways related to collagen synthesis, influencing COL4A1 activity and the preservation of basement membranes. Yoda1, a selective activator of the Piezo1 ion channel, induces calcium influx through Piezo1 activation. Yoda1's modulation of Piezo1-mediated calcium signaling directly influences pathways related to collagen synthesis, impacting COL4A1 activity and the preservation of basement membrane structure. Dibutyryl cAMP, Bay K 8644, 8-Bromo-cGMP, Resolvin D1, Nobiletin, and Ciclopirox, each with their specific mechanisms of action, contribute to the nuanced regulation of COL4A1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) is a lipid mediator found in arachidonic acid. It activates the EP receptors, particularly EP2 and EP4, leading to increased cAMP levels. In the context of COL4A1 activation, PGE2's signaling through EP receptors may influence pathways related to collagen synthesis, directly modulating COL4A1 activity and contributing to the maintenance of basement membranes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator that increases intracellular cAMP levels. Elevated cAMP levels can activate protein kinase A (PKA). In the context of COL4A1 activation, forskolin's stimulation of cAMP/PKA signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the maintenance of basement membrane structure. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that facilitates calcium influx into cells. Increased intracellular calcium levels can activate various signaling pathways. In the context of COL4A1 activation, A23187's induction of calcium signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the preservation of basement membrane integrity. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost is a prostacyclin analog that activates prostacyclin receptors, leading to increased cAMP levels. In the context of COL4A1 activation, iloprost's signaling through prostacyclin receptors may influence pathways related to collagen synthesis, directly modulating COL4A1 activity and contributing to the maintenance of basement membranes. | ||||||
YODA 1 | 448947-81-7 | sc-507361 | 10 mg | $215.00 | ||
Yoda1 is a selective activator of the Piezo1 ion channel, which plays a role in mechanotransduction. Activation of Piezo1 can lead to calcium influx. In the context of COL4A1 activation, Yoda1's activation of Piezo1-mediated calcium signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the preservation of basement membrane structure. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
Epicatechin is a flavonoid that exhibits antioxidant properties. It may impact redox-sensitive pathways. In the context of COL4A1 activation, epicatechin's antioxidant effects may directly modulate redox-sensitive pathways related to collagen synthesis, influencing COL4A1 activity and the maintenance of basement membranes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that mimics the action of endogenous cAMP. It can activate cAMP-dependent pathways, including protein kinase A (PKA). In the context of COL4A1 activation, dibutyryl cAMP's stimulation of cAMP/PKA signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the preservation of basement membrane integrity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 is a dihydropyridine L-type calcium channel activator that increases calcium influx into cells. Elevated intracellular calcium levels can activate various signaling pathways. In the context of COL4A1 activation, Bay K 8644's induction of calcium signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the maintenance of basement membrane structure. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
8-Bromo-cGMP is a cell-permeable analog of cyclic guanosine monophosphate (cGMP). It activates cGMP-dependent pathways, including protein kinase G (PKG). In the context of COL4A1 activation, 8-Bromo-cGMP's stimulation of cGMP/PKG signaling may directly modulate pathways related to collagen synthesis, influencing COL4A1 activity and the preservation of basement membrane integrity. | ||||||
Resolvin D1 | 872993-05-0 | sc-204877 sc-204877A | 10 µg 25 µg | $262.00 $614.00 | 1 | |
Resolvin D1 is a specialized pro-resolving lipid mediator found in docosahexaenoic acid. It activates G protein-coupled receptors, such as ChemR23. In the context of COL4A1 activation, Resolvin D1's signaling through ChemR23 may influence pathways related to collagen synthesis, directly modulating COL4A1 activity and contributing to the maintenance of basement membranes. | ||||||