COA5 Activators
Chemical activators of COA5 can facilitate its role within the mitochondrial electron transport chain, particularly in the assembly and maintenance of Complex IV, also known as cytochrome c oxidase. Coenzyme Q10, functioning as an electron carrier within the lipid membrane, ensures a steady flow of electrons to Complex IV, thus maintaining an environment conducive to COA5 activity. The presence of Copper(II) sulfate provides essential copper ions for the complex, directly supporting the metal centers that are crucial for the catalytic action of the complex where COA5 is involved. Succinic acid, as a substrate for Complex II, can enhance the electron flow through the chain, indirectly promoting COA5 activity. Similarly, Nicotinamide adenine dinucleotide (NADH) supplies electrons to Complex I, increasing the electron throughput and indirectly enhancing COA5's role by upregulating the demand for complex assembly and function.
Ubiquinol serves as a replenishing electron donor within the chain, synergistically supporting COA5 function by sustaining the electron flow necessary for Complex IV's activity. Alpha-lipoic acid, by enhancing mitochondrial enzyme functions, can indirectly aid the electron transport chain, thereby supporting COA5's role. Riboflavin, through its role in FAD synthesis, indirectly maintains electron transfer across Complex II, which feeds into the electron transport chain. Ferrous sulfate, by providing iron, is essential for forming heme groups within cytochromes, indirectly supporting COA5 function in Complex IV. Lastly, ascorbic acid actively contributes to the reduction of cytochrome c, ensuring a constant influx of electrons to Complex IV, thus supporting the activities of COA5.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 interacts with COA5 as part of the mitochondrial electron transport chain, where COA5 functions. It helps in the proper functioning of the complex, thereby supporting COA5's role in assisting the assembly and maintenance of complex IV. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is a critical component of cytochrome c oxidase, the complex where COA5 is involved. Copper(II) sulfate provides copper ions that can be integrated into the complex, supporting COA5's role in assembling the metal centers of the complex, essential for its catalytic activity. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinic acid participates in the Krebs cycle and serves as a substrate for Complex II, which is connected to the electron transport chain where COA5 is active. Providing substrate can enhance electron flow through the chain, indirectly supporting COA5's role. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NADH is a substrate for Complex I in the electron transport chain, which links to the activity of COA5 in complex IV. The presence of NADH can increase electron flow, indirectly enhancing the activity of COA5 by increasing the demand for its role in complex assembly and function. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid acts as a cofactor for mitochondrial enzymes, and its presence can enhance the overall mitochondrial function, including the electron transport chain where COA5 operates. This can indirectly support COA5's role in electron transfer within the mitochondrial membrane. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin is a precursor for FAD, which is a cofactor for Complex II in the electron transport chain. By supporting Complex II activity, riboflavin can indirectly enhance the electron flow through the chain, facilitating the environment in which COA5 is active. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid can reduce cytochrome c, which is an essential step in the electron transport chain, directly before the electron is transferred to Complex IV. This reduction supports the activity of COA5 by ensuring a continuous supply of electrons to the complex where COA5 is active. | ||||||