claudin-11 Inhibitors
The class of claudin-11 inhibitors encompasses a variety of chemical compounds that can potentially modulate the function and activity of claudin-11, either directly or indirectly by influencing the biochemical pathways and cellular processes that claudin-11 is involved in. Staurosporine, a potent protein kinase inhibitor, for instance, can inhibit PKC which is known to regulate the function of claudins including claudin-11. Reduced PKC activity via Staurosporine can lead to decreased phosphorylation of claudin-11, resulting in destabilization of tight junctions, where claudin-11 plays an essential role. Similarly, LY294002 and Wortmannin, both PI3K inhibitors, can affect claudin-11 function by reducing Akt activity, a known influence on claudin-11 and tight junction integrity. PD98059 and U0126, selective MEK inhibitors, can inhibit the MAPK/ERK pathway, whichis integral to claudin-11's function in ERK-mediated signal transduction at tight junctions. The JNK inhibitor SP600125 and Src family kinase inhibitor PP2 also demonstrate potential for modulating claudin-11 function, as these kinases actively participate in the regulation of claudin-11.
The ROCK inhibitor Y-27632 is another notable compound, with its capacity to affect claudin-11 by inhibiting the RhoA/ROCK pathway, a critical regulator of tight junctions. Similarly, SB431542, an ALK5 receptor inhibitor, can influence claudin-11 function via its impact on the TGF-β signaling pathway. Two other chemicals in this class, Wiskostatin and BAPTA, exert their influence through different mechanisms. Wiskostatin, an N-WASP inhibitor, can interfere with claudin-11 function by inhibiting N-WASP, which is known to regulate tight junctions through its role in actin cytoskeleton remodeling. BAPTA, a calcium chelator, can inhibit claudin-11 by chelating calcium, an element critical for the function of tight junctions and claudin-11. Lastly, Genistein, a tyrosine kinase inhibitor, can affect claudin-11 by inhibiting tyrosine kinases, which are known regulators of claudin-11 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC, which is known to regulate the function of claudins including claudin-11. By inhibiting PKC, Staurosporine can reduce phosphorylation of claudin-11, leading to destabilization of tight junctions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in the regulation of tight junctions through the Akt signaling pathway. Inhibition of PI3K by LY294002 can lead to reduced Akt activity, thus affecting claudin-11 function and tight junction integrity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MEK inhibitor that can inhibit the MAPK/ERK pathway. Claudin-11 is involved in ERK-mediated signal transduction at tight junctions, so inhibiting this pathway can potentially reduce claudin-11's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Sp600125 is a JNK inhibitor. Claudin-11 function can be affected by the JNK signaling pathway, so by inhibiting JNK, SP600125 can potentially interfere with the function of claudin-11. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible PI3K inhibitor. By inhibiting PI3K, Wortmannin can reduce Akt activity, which is known to influence claudin-11 function and tight junction integrity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, an effector of RhoA. RhoA and ROCK are involved in the regulation of tight junctions. Y-27632 can inhibit the function of claudin-11 by inhibiting the RhoA/ROCK pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a selective inhibitor of the ALK5 receptor, which is involved in the TGF-β signaling pathway. Claudin-11 is known to be regulated by this pathway; thus, inhibition by SB431542 can affect claudin-11 function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. Claudin-11 is known to be regulated by Src kinases, therefore, PP2 can inhibit the function of claudin-11 by inhibiting Src kinases. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an N-WASP inhibitor. N-WASP is involved in the regulation of tight junctions and claudin-11 function through its role in actin cytoskeleton remodeling. Wiskostatin can interfere with the function of claudin-11 by inhibiting N-WASP. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
BAPTA is a calcium chelator. Calcium is critical for the function of tight junctions and claudin-11. By chelating calcium, BAPTA can inhibit the function of claudin-11. | ||||||