BAPTA, Free Acid CAS: 85233-19-8
MF: C22H24N2O10
MW: 476.44
A selective calcium chelator with 105-fold greater affinity for Ca2+ than Mg2+.

BAPTA, Free Acid (CAS 85233-19-8)

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同义词: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
应用; A selective calcium chelator with 105-fold greater affinity for Ca2+ than Mg2+
CAS号码: 85233-19-8
纯度: ≥ 97%
分子量: 476.44
分子式: C22H24N2O10
* 参考分析证明 大量特定数据 (包括水 含量).
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BAPTA, Free Acid (1,2-bis-(o-Aminophenoxy)-ethane-N,N,N′,N′-tetraacetic acid) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. BAPTA, Free acid is not cell permeable and is useful for manipulating extracellular Ca2+ levels. BAPTA is closely related to the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid] (sc-3593), but is less effected by pH changes and are more efficient at taking up and releasing Ca2+.
Additional BAPTA chelators available:
BAPTA tetrapotassium salt (sc-202076)
BAPTA/AM (sc-202488)
BAPTA-APM (sc-206966)
BAPTA-TMFM (sc-212043)
5,5i difluoro Bapta(AM) (sc-217247)
5,5i difluoro Bapta(K+ Salt) (sc-217248)
Bapta-FF (AM) (sc-217696)
BAPTA, Tetrasodium Salt (sc-278716)


参考文献

1. Tsien, R.Y., et al. 1980. Biochemistry. 19: 2396-2404. PMID: 6770893
2. Kijima, H., et al. 1988. J. Physiol. 403: 135-149. PMID: 3150982
3. Tanabe, N., et al. 1988. Neurosci. Lett. 92: 52-57. PMID: 2847089
4. Tymianski, M., et al. 1994. J. Neurophysiol. 72: 1973-1992. PMID: 7823112
5. Li, L., et al. 1995. J. Cell. Physiol. 163: 105-114. PMID: 7896886
6. Hardie, R.C. 2005. Cell Calcium. 38: 547-556. PMID: 16140375

物理状态 :
Solid
溶解度 :
Soluble in water (partly miscible), DMSO (25 mg/ml), DMF (25 mg/ml), 0.3 N NaHCO3 (50 mg/ml), aqueous Acid, and aqueous Base.
保存 :
Store at -20° C
熔点 :
174° C
沸点 :
766.57° C at 760 mmHg (Predicted)
密度 :
1.49 g/cm3 (Predicted)
折射率 :
n20D 1.66 (Predicted)
pK值 :
pKa: 1.40 (Predicted), pKb: 5.96 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
MC0423000
PubChem CID :
104751
默克索引 :
14: 957
MDL 号码 :
MFCD00036255
Beilstein 注册 :
5192406
SMILES :
C1=CC=C(C(=C1)N(CC(=O)O)CC(=O)O)OCCOC2=CC=CC=C2N(CC(=O)O)CC(=O)O

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PMID: # 30156610  Coutinho, AGG.|Biscaia, SMP.|Fernandez, R.|Tararthuch, AL.| et al. 2018. Braz. J. Med. Biol. Res. 51: e7417.

PMID: # 28299994  Zhang, SM.|Yu, LL.|Qu, T.|Hu, Y.|Yuan, DZ.|Zhang, S.|Xu, Q.|Zhao, YB.|Zhang, JH.|Yue, LM.| et al. 2017. Reprod Sci. 24: 1639-1646.

PMID: # 28497254  Angstadt, JD. et al. 2017. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 203: 613-633.

PMID: # 27865353  Mohan, S. et al. 2016. Nutrition research (New York, N.Y.). 36: 1114-1120.

PMID: # 26673139  Galindo-Villegas, J. et al. 2016. J. Immunol. 196: 738-49.

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