CLASP1 Activators
Microtubule-stabilizing agents are a class of small molecules that stabilize microtubules, which are dynamic structural components of the cytoskeleton. These agents can indirectly impact the activity of Cytoplasmic Linker Associated Protein 1 (CLASP1) by promoting its association with microtubules and enhancing its function in regulating microtubule dynamics. CLASP1 is a microtubule-associated protein that plays a crucial role in regulating microtubule dynamics within cells. Microtubules are essential structural components of the cytoskeleton, and their dynamic instability is crucial for processes like cell division, intracellular transport, and cell motility. CLASP1 interacts with microtubules to modulate their stability and dynamics, making it a key player in various cellular functions.
Microtubule-stabilizing agents are primarily used in cancer therapy due to their ability to disrupt mitosis and inhibit cell division in rapidly dividing cancer cells. While they primarily target microtubules, their impact on CLASP1 and other microtubule-associated proteins underscores the intricate regulation of microtubule dynamics within cells. These activators might function by increasing CLASP1's binding affinity to microtubules, promoting its localization to specific cellular regions, or modulating its post-translational modifications.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel is one of the most well-known microtubule-stabilizing agents. It binds to microtubules and inhibits their depolymerization, effectively locking microtubules in a stable state. This stabilization of microtubules can promote the association of CLASP1 with microtubules, enhancing its role in regulating microtubule dynamics. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel, like paclitaxel, stabilizes microtubules by inhibiting their depolymerization. This stabilization can lead to increased CLASP1 binding to microtubules, contributing to the regulation of microtubule dynamics and cellular processes like mitosis. | ||||||
Epothilone A | 152044-53-6 | sc-207628 sc-207628A | 10 µg 1 mg | $210.00 $1000.00 | 1 | |
Epothilones are a class of compounds with microtubule-stabilizing properties similar to paclitaxel and docetaxel. They enhance microtubule stability and, consequently, may affect CLASP1 function by increasing its interaction with microtubules. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide is a natural product that stabilizes microtubules by a mechanism distinct from paclitaxel. It has been shown to enhance the association of CLASP1 with microtubules, potentially affecting its role in microtubule dynamics regulation. | ||||||