Date published: 2025-10-23

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CIRP Inhibitors

CIRP inhibitors are a subclass of chemical entities that exert their effects by targeting the Cold-Inducible RNA-Binding Protein (CIRP). This class of molecules is characterized by their specific interactions with the CIRP protein, a vital component of cellular machinery involved in various molecular processes. CIRP itself is recognized for its responsiveness to external stressors, such as exposure to cold temperatures and cellular stress. It serves as a nucleic acid-binding protein with multifaceted roles in regulating RNA stability, translation, and gene expression under adverse conditions. The structural diversity within the realm of CIRP inhibitors permits scientists to explore an array of chemical arrangements and binding motifs that facilitate their affinity for CIRP.

By binding to CIRP, these inhibitors aim to modulate its activity and, consequently, influence downstream cellular responses. The intricacies of CIRP's involvement in mediating stress responses and orchestrating cellular adaptation make it an intriguing target for intervention. Ongoing investigations into the mechanism of action of CIRP inhibitors seek to unravel the complex interplay between these compounds and the CIRP protein. Researchers are delving into the molecular details of how these inhibitors influence CIRP's functions, potentially offering insights into fundamental cellular processes, stress adaptation, and related signaling pathways. As researchers gain a deeper understanding of the interactions between CIRP and its inhibitors, it paves the way for the exploration of novel avenues in cellular biology and the potential to uncover broader implications for cellular homeostasis and stress management.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Palbociclib

571190-30-2sc-507366
50 mg
$315.00
(0)

Palbociclib is a small molecule inhibitor that selectively targets CDK4 and CDK6, preventing their interaction with cyclin D and thereby inhibiting progression through the G1 phase of the cell cycle. It's studied in the research of hormone receptor-positive, HER2-negative a

Ribociclib

1211441-98-3sc-507367
10 mg
$450.00
(0)

Similar to palbociclib, ribociclib is a CDK4/6 inhibitor investigated for the of hormone receptor-positive, HER2-negative advanced. It functions by blocking CDK4/6-cyclin D complexes, leading to G1 cell cycle arrest.

Abemaciclib

1231929-97-7sc-507342
10 mg
$110.00
(0)

Abemaciclib is another CDK4/6 inhibitor used in the research of hormone receptor-positive, HER2-negative. It has shown efficacy in inhibiting cell cycle progression and inducing apoptosis.

Dinaciclib

779353-01-4sc-364483
sc-364483A
5 mg
25 mg
$242.00
$871.00
1
(0)

Dinaciclib is a broader spectrum CDK inhibitor that targets CDK1, CDK2, CDK5, and CDKIt has potential applications due to its wide-ranging effects on cell cycle regulation and transcriptional control.

Flavopiridol Hydrochloride

131740-09-5sc-207687
10 mg
$311.00
(2)

Flavopiridol is a semi-synthetic flavonoid compound that inhibits multiple CDKs, including CDK1, CDK2, CDK4, CDK6, and CDKIt has been studied in research models for its potential as an anti-cancer agent by disrupting cell cycle progression and transcriptional regulation.