CHMP4C Inhibitors
CHMP4C inhibitors are a class of compounds that specifically target and inhibit the activity of CHMP4C, a member of the Charged Multivesicular Body Protein family and a crucial component of the ESCRT-III (Endosomal Sorting Complex Required for Transport III) complex. CHMP4C plays a pivotal role in several membrane remodeling processes, most notably in the abscission stage of cytokinesis, where it regulates the final separation of daughter cells. In this context, CHMP4C ensures proper timing and coordination of the abscission process, preventing premature cell division, which could lead to chromosomal instability or cell cycle defects. Additionally, CHMP4C contributes to endosomal sorting, facilitating the degradation of cellular cargo through multivesicular body (MVB) formation and lysosomal degradation pathways.
The mechanism of CHMP4C inhibitors involves disrupting the protein's ability to polymerize or interact with other ESCRT-III components, thereby blocking its role in membrane scission and cargo sorting processes. By inhibiting CHMP4C, researchers can explore how this protein controls membrane dynamics during cell division and intracellular trafficking. These inhibitors provide valuable insights into the importance of CHMP4C in cellular homeostasis and its regulatory role in preventing errors during cytokinesis. Studying CHMP4C inhibition also helps to illuminate the broader role of ESCRT-III in membrane repair, vesicle formation, and cargo transport across various biological contexts. Through the use of CHMP4C inhibitors, scientists gain a clearer understanding of how cells maintain integrity during division and how membrane-related processes are fine-tuned by proteins like CHMP4C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may downregulate CHMP4C through histone deacetylase inhibition, leading to a more acetylated and less transcriptionally repressed chromatin state around the CHMP4C gene locus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent can decrease CHMP4C expression by incorporating into DNA and RNA, disrupting the normal methylation pattern of the CHMP4C gene promoter, which is critical for its transcriptional control. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 could reduce CHMP4C levels by preventing the degradation of ubiquitinated proteins, thereby creating a cellular environment that hinders the transcriptional machinery needed for CHMP4C gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This compound can decrease the expression of CHMP4C by inhibiting phosphoinositide 3-kinases, which would attenuate the PI3K/AKT signaling cascade that can control the transcription of the CHMP4C gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is likely to downregulate CHMP4C by inhibiting mTORC1, which can lead to reduced activity of S6K1 and 4EBP1, two downstream targets that are often involved in the control of gene expression, including that of CHMP4C. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 may decrease CHMP4C expression by specifically inhibiting the activin receptor-like kinases, which are part of the TGF-beta signaling that can govern the transcription of the CHMP4C gene. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone could downregulate CHMP4C by activating glucocorticoid receptors, which may bind to glucocorticoid response elements in the CHMP4C gene promoter region and reduce its transcriptional activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib may reduce CHMP4C expression by inhibiting the 26S proteasome, leading to accumulation of misfolded proteins and cellular stress, which can trigger a decrease in the transcription of various genes, potentially including CHMP4C. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could inhibit CHMP4C expression by downregulating transcription factors such as NF-κB, which may bind to the CHMP4C promoter region and are essential for its transcriptional initiation. | ||||||