CHAC2 Inhibitors
CHAC2 inhibitors are a class of compounds that specifically target and inhibit the activity of the CHAC2 protein, a member of the γ-glutamylcyclotransferase enzyme family. CHAC2, along with its closely related family members, plays a role in modulating intracellular glutathione levels by catalyzing the degradation of glutathione, a key antioxidant in cellular defense against oxidative stress. By controlling glutathione breakdown, CHAC2 influences cellular redox homeostasis and other metabolic processes linked to cellular health and signaling. Inhibiting CHAC2 disrupts its ability to degrade glutathione, thereby altering the balance of glutathione within the cell and affecting redox-sensitive processes.
The mechanism of CHAC2 inhibitors involves binding to the enzyme's active site, preventing it from interacting with glutathione and performing its catalytic function. This inhibition is used by researchers to explore the role of CHAC2 in maintaining cellular redox balance and its broader influence on intracellular signaling pathways that are sensitive to oxidative stress. CHAC2 inhibitors provide insights into how the regulation of glutathione levels affects processes such as apoptosis, cell differentiation, and response to environmental stressors. By modulating CHAC2 activity, scientists can study the enzyme's involvement in antioxidant defense mechanisms and how disruptions in glutathione metabolism contribute to cellular dysfunction and changes in metabolic states. These inhibitors are valuable tools for investigating the precise role of CHAC2 in glutathione metabolism and redox regulation across various biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
Caspase inhibitor that can stabilize cellular processes by inhibiting apoptosis, a pathway CHAC2 may regulate. | ||||||
Q-VD-OPH | 1135695-98-5 | sc-222230 | 5 mg | $782.00 | 5 | |
A broad-spectrum caspase inhibitor that can sustain cell survival, potentially affecting CHAC2's apoptotic role. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $94.00 $343.00 | 97 | |
Inhibits RIP1 kinase to control necroptosis, a cell death mechanism that CHAC2 may be involved in. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Autophagy inhibitor acting on PI3K, which could intersect with CHAC2's function in cellular catabolism. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Promotes the degradation of Vps34 PI3K complexes, possibly affecting CHAC2's role in autophagy. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
V-ATPase inhibitor that alters endosomal-lysosomal acidification, potentially impacting CHAC2's function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Inhibits the mitochondrial permeability transition pore, potentially influencing CHAC2's role in apoptosis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
ER stress inducer that disrupts calcium homeostasis, potentially affecting CHAC2-related stress responses. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress by inhibiting N-linked glycosylation, which may affect CHAC2's function in protein folding. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Selectively inhibits dephosphorylation of eIF2α, potentially influencing CHAC2's role in the stress response. | ||||||