Centaurin γ3 Inhibitors
Chemical inhibitors of Centaurin γ3 can exert their inhibitory effects through various mechanisms within the cellular signaling pathways. LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3Ks) inhibitors, can effectively inhibit the PI3K signaling cascade. Since Centaurin γ3 is associated with the PI3K pathway, the activity of Centaurin γ3 can be disrupted as these inhibitors prevent PI3K-mediated activation of downstream targets. Similarly, ML141, a selective inhibitor of Cdc42 GTPase, and NSC23766, which specifically blocks Rac1 GTPase, can indirectly hinder Centaurin γ3 function by disturbing the GTPase signaling pathways that Centaurin γ3 may be involved with. SecinH3, targeting cytohesins, and ZCL278, a Cdc42 effector binding inhibitor, can also impede signaling processes that can lead to the functional inhibition of Centaurin γ3's role in those pathways.
Furthermore, IPA-3 selectively inhibits PAK1, a kinase that Centaurin γ3 might regulate, thereby disrupting Centaurin γ3's indirect signaling mechanisms. The same principle applies to CASIN and EHop-016, which inhibit Cdc42 and Rac1, respectively, affecting the actin cytoskeleton organization and cellular processes that Centaurin γ3 is implicated in. Thus, the inhibition of these GTPases can result in disrupted function of Centaurin γ3. Tozasertib, an Aurora kinase inhibitor, can interfere with the role of Centaurin γ3 in cell division and mitosis. Additionally, AZD8055 inhibits mTOR within the PI3K/AKT signaling, which can lead to the inhibition of Centaurin γ3 by affecting the pathway it is part of. Lastly, GSK2334470, an inhibitor of PDK1, disrupts the PI3K pathway and can lead to decreased activity of Centaurin γ3 by inhibiting a kinase upstream in its signaling pathway. Each of these chemicals, by targeting specific proteins or enzymes within the associated pathways of Centaurin γ3, can lead to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This chemical is a known inhibitor of phosphoinositide 3-kinases (PI3Ks). Centaurin γ3, being part of the signaling pathway that involves PI3Ks, can be functionally inhibited by LY294002 as it prevents the PI3K-mediated activation of downstream targets that Centaurin γ3 may be involved with. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. It binds irreversibly to PI3K, inhibiting its activity. Since Centaurin γ3 is associated with PI3K signaling pathways, the inhibition of PI3K by Wortmannin can lead to the functional inhibition of Centaurin γ3's role in said pathways. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of the Cdc42 GTPase. Given that Centaurin γ3 has GTPase-activating protein related domains, inhibiting Cdc42 can disrupt the GTPase signaling pathway and indirectly inhibit the function of Centaurin γ3 within this pathway. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 targets cytohesins, which are guanine nucleotide exchange factors for ADP-ribosylation factors. By inhibiting these exchange factors, SecinH3 can disrupt the ARF-mediated signaling processes, which Centaurin γ3 might be involved in, thus indirectly inhibiting its function. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
This chemical is a Cdc42 GTPase inhibitor that blocks the binding between Cdc42 and its effectors. By doing so, ZCL278 can indirectly inhibit Centaurin γ3 by disrupting the downstream signaling cascade in which it may participate. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
IPA-3 selectively inhibits the PAK1, a serine/threonine kinase that can be involved in Centaurin γ3-regulated pathways. By inhibiting PAK1, IPA-3 can disrupt signaling that may indirectly inhibit the function of Centaurin γ3. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
CASIN is a Cdc42 inhibitor that can disrupt the actin cytoskeleton dynamics and cellular processes regulated by Cdc42. As Centaurin γ3 is involved in cytoskeletal organization, inhibiting Cdc42 with CASIN can lead to the functional inhibition of Centaurin γ3. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016 inhibits Rac1, which impacts actin cytoskeleton organization. Since Centaurin γ3 is implicated in cytoskeletal organization, Rac1 inhibition by EHop-016 can result in disrupted function of Centaurin γ3. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Tozasertib is an Aurora kinase inhibitor. Given the involvement of Centaurin γ3 in cell division and mitosis, where Aurora kinases play a crucial role, inhibition of these kinases by Tozasertib can indirectly inhibit the functional role of Centaurin γ3 in these processes. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is an inhibitor of mTOR, a serine/threonine kinase involved in PI3K/AKT signaling. Centaurin γ3 is part of the PI3K signaling pathway, and thus inhibition of mTOR by AZD8055 can indirectly inhibit Centaurin γ3 function. | ||||||