CENP-E Activators
CENP-E activators belong to a distinctive chemical class characterized by their ability to modulate the activity of a protein known as Centromere-associated protein E (CENP-E). CENP-E is a motor protein essential for proper chromosome segregation during cell division, specifically during the metaphase stage of mitosis. It plays a crucial role in ensuring that each chromosome aligns correctly at the cell's equatorial plane before being pulled apart into the daughter cells. Activators of CENP-E are compounds that have been designed or discovered to enhance the function of this motor protein, which in turn, contributes to the maintenance of genomic stability.
The primary mechanism by which CENP-E activators exert their effects is by enhancing the motor activity of CENP-E. These molecules interact with specific binding sites on CENP-E and promote its ATPase activity, which is critical for the motor protein's movement along microtubules. As a result, CENP-E activators facilitate the efficient capture and alignment of chromosomes during mitosis, ultimately ensuring the fidelity of chromosome segregation. This regulation of CENP-E function is essential for the accurate distribution of genetic material and the prevention of aneuploidy, a condition characterized by an abnormal number of chromosomes in daughter cells, which can lead to various genetic disorders and diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, potentially affecting CENP-E function in mitosis by altering microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule destabilizer, could impact CENP-E activity by altering microtubule dynamics crucial for mitosis. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Disrupts microtubule polymerization, potentially influencing CENP-E function in chromosome segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Inhibits microtubule formation, potentially affecting CENP-E activity in mitotic spindle assembly. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor, potentially affecting CENP-E function in spindle checkpoint control. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits kinesin Eg5, potentially affecting CENP-E by altering spindle dynamics. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
A Plk1 inhibitor, could impact CENP-E activity by affecting polo-like kinase 1 involved in mitosis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, might affect CENP-E indirectly by influencing PI3K/Akt signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor, could impact gene expression and chromatin structure, potentially influencing CENP-E function. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
A specific CENP-E inhibitor, providing insights into CENP-E modulation through microtubule interaction. | ||||||