CDNF Inhibitors
Chemical inhibitors of Cerebral Dopamine Neurotrophic Factor (CDNF) can effectively negate the neuroprotective functions of this protein through various mechanisms. 6-Hydroxydopamine, a neurotoxic compound, selectively destroys dopaminergic and noradrenergic neurons, which are the primary sites of CDNF action, leading to functional inhibition. MPP+ (1-Methyl-4-phenylpyridinium) operates in a similar fashion by being taken up by dopaminergic neurons and causing cell death, thus counteracting the neuroprotective role of CDNF. Rotenone, an inhibitor of mitochondrial complex I, disrupts the mitochondrial function that CDNF is known to support, and Paraquat induces oxidative stress, overwhelming cellular defenses that CDNF helps to bolster. Thapsigargin and Tunicamycin both induce endoplasmic reticulum stress by disrupting calcium homeostasis and glycosylation, respectively, which effectively inhibits the ER stress-alleviating function of CDNF.
Additionally, chemicals such as Endosulfan and Alloxan induce neuronal cell death and β-cell destruction by oxidative stress and excitotoxicity, processes against which CDNF provides protection, thereby indirectly inhibiting the protein's function. Colchicine's disruption of microtubule polymerization undermines the structural integrity of neurons, which CDNF helps to maintain, leading to its functional inhibition. β-Bungarotoxin blocks neurotransmitter release, preventing CDNF from exerting its protective effects in synaptic environments. 3-Nitropropionic acid irreversibly inhibits succinate dehydrogenase, leading to neuronal cell death, thereby inhibiting CDNF's neuroprotective role. Lastly, Methylmercury causes oxidative damage and apoptotic cell death in neurons, promoting the cellular demise that CDNF is specifically tasked to protect against, and thus functionally inhibiting the protein's protective capabilities.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Hydroxydopamine hydrochloride | 28094-15-7 | sc-203482 | 100 mg | $149.00 | 8 | |
This neurotoxic compound selectively destroys dopaminergic and noradrenergic neurons. CDNF is known for its neuroprotective role in dopaminergic systems. By damaging these neurons, 6-Hydroxydopamine effectively negates the protective effect that CDNF has in these contexts, resulting in functional inhibition. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. CDNF has been shown to protect dopaminergic neurons by improving mitochondrial function. Therefore, by impairing mitochondrial function, Rotenone can reduce the efficacy of CDNF's neuroprotective role, leading to functional inhibition. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat induces oxidative stress by forming reactive oxygen species. CDNF has been shown to protect cells from stress-induced damage. Therefore, by overwhelming the cellular antioxidant defenses, Paraquat can indirectly inhibit the protective function of CDNF. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump inhibitor that disrupts calcium homeostasis. Since CDNF is known to affect ER stress positively, Thapsigargin would negate this effect by inducing ER stress, thus functionally inhibiting CDNF. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, leading to ER stress. CDNF is known to alleviate ER stress, and by inducing it, Tunicamycin can counteract CDNF's function, leading to functional inhibition. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $54.00 | ||
Alloxan induces diabetes by specifically destroying insulin-producing β-cells in the pancreas. Since CDNF also has a role in the survival of pancreatic β-cells, the destructive effect of Alloxan effectively inhibits the function of CDNF in pancreatic cell survival. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization. CDNF's neuroprotective effects involve normal cytoskeletal functioning; thus, Colchicine can indirectly inhibit CDNF's function by disrupting cell structure and transport mechanisms essential for neuronal survival. | ||||||
3-Nitropropionic acid | 504-88-1 | sc-214148 sc-214148A | 1 g 10 g | $82.00 $459.00 | ||
This toxin irreversibly inhibits succinate dehydrogenase in mitochondria, leading to energy depletion and neuronal cell death. CDNF promotes neuronal survival, so by causing neuronal death, 3-Nitropropionic acid functionally inhibits the neuroprotective role of CDNF. | ||||||