CDK5RAP2 Activators
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels, which in turn activate PKA. PKA can phosphorylate various proteins including those involved in the regulation of the cell cycle. CDK5RAP2, being a regulator of CDK5 in neuronal cells, can have its protein-protein interactions influenced by PKA-mediated phosphorylation, thus enhancing its activity in neuronal development. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which degrades cAMP. By inhibiting PDE4, rolipram increases cAMP concentrations, which activate PKA and can potentially enhance CDK5RAP2 activity by similar mechanisms as forskolin, particularly affecting its role in microtubule organization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit several protein kinases, which can alter the phosphorylation state of proteins involved in cell cycle regulation. By modulating these pathways, EGCG can create an environment that favors the activation of CDK5RAP2's function in centrosome cohesion and spindle assembly during mitosis. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and prevents their disassembly. CDK5RAP2 is involved in microtubule stabilization at the centrosome. By promoting microtubule stability, paclitaxel can enhance the microtubule-organizing activity of CDK5RAP2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression by activating nuclear receptors. It can influence the cell cycle and neuronal differentiation pathways that involve CDK5RAP2, potentially enhancing its role in neurogenesis and neuronal migration. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine enhances the phosphorylation levels of cellular proteins by inhibiting various kinases. This can lead to the activation of pathways that indirectly promote CDK5RAP2's role in centrosome function and gamma-tubulin ring complex stabilization. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is a polyamine that has been found to stabilize microtubules and enhance autophagy. By stabilizing microtubules, spermidine can indirectly support the microtubule anchoring function of CDK5RAP2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). HDAC inhibition can lead to a relaxed chromatin structure, allowing for the expression of genes involved in cell cycle regulation and differentiation, potentially enhancing the cellular context for CDK5RAP2 function. | ||||||
N-Benzoyladenosine | 4546-55-8 | sc-257831 | 1 g | $106.00 | ||
This adenosine analog has been shown to affect the cAMP pathway by acting as an agonist at adenosine receptors, which can lead to PKA activation. PKA then may enhance CDK5RAP2 activity by phosphorylation mechanisms similar to those induced by forskolin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which is involved in microtubule dynamics. Inhibition of GSK-3 can result in an increase in beta-catenin levels, which indirectly might affect the stability of microtubules and enhance the role of CDK5RAP2 in microtubule organization. | ||||||