CD47 Inhibitors

CD47 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Cluster of Differentiation 47 (CD47) protein. CD47 is a cell surface glycoprotein that is widely expressed on various cells, including red blood cells, immune cells, and cancer cells. It plays a crucial role in regulating several cellular processes, such as phagocytosis, immune responses, and vascular development. CD47 acts as a don't eat me signal by interacting with its receptor on macrophages, inhibiting their ability to engulf and remove the CD47-expressing cells through phagocytosis. CD47 inhibitors work by specifically targeting the CD47 protein, disrupting its interaction with the receptor on macrophages. By doing so, these inhibitors may modulate the phagocytic response of macrophages and influence immune responses against CD47-expressing cells, including cancer cells. Research into CD47 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in regulating phagocytosis and immune responses. The study of CD47 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms that govern immune evasion and immune surveillance in various physiological and pathological contexts.