Cd302 Inhibitors
Chemical inhibitors of Cd302 can affect its function through various mechanisms, primarily by disrupting signaling pathways that Cd302 is part of, which are integral for cell adhesion and migration. Wortmannin and LY294002 serve as phosphoinositide 3-kinase (PI3K) inhibitors, directly impeding the PI3K/Akt pathway signaling. The inhibition of this pathway can lead to reduced actin cytoskeleton remodeling, a process essential for Cd302-mediated cell adhesion and migration. Similarly, PP2 and SU6656, as selective inhibitors of Src family tyrosine kinases, can interfere with signaling cascades that regulate the actin cytoskeleton and, consequently, the role of Cd302 in these pathways. Inhibition by these chemicals can lead to disrupted cell adhesion and impaired migratory responses that Cd302 typically facilitates.
Bosutinib and Dasatinib, which are tyrosine kinase inhibitors targeting Src and Abl kinases, can also inhibit Cd302 function by obstructing the kinases that participate in signaling for cell adhesion and the dynamic rearrangement of the cytoskeleton. Maraviroc, by antagonizing the CCR5 receptor, can indirectly affect Cd302's role by altering the chemotactic responses of cells, whereas SB203580 and SP600125 can inhibit Cd302 function through their action on p38 MAP kinase and c-Jun N-terminal kinase (JNK), respectively. Both MAPK and JNK pathways are involved in the regulation of cellular adhesion and migration. Y-27632, a ROCK inhibitor, can compromise the integrity of the actin cytoskeleton and cell motility, thus inhibiting the function of Cd302 in these cellular processes. PF-562271 and Cilengitide, by inhibiting focal adhesion kinase (FAK) and integrins respectively, can also lead to reduced Cd302 function by impeding the signaling mechanisms that control cell adhesion and migration, which are critical to Cd302 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. Given that Cd302 is involved in cellular adhesion and migration, PI3K inhibition can disrupt actin cytoskeleton remodeling, which is necessary for the function of Cd302 in mediating cell adhesion and migration. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor, similar to wortmannin. It would inhibit Cd302 function by preventing the PI3K/Akt pathway signaling, which is crucial for the regulation of cell migration and cytoskeletal rearrangement, processes in which Cd302 is implicated. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases are involved in signaling pathways that regulate the actin cytoskeleton, and since Cd302 is a part of these pathways through its role in cell adhesion, PP2 can inhibit Cd302 function by disrupting these signaling pathways. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $57.00 $133.00 | 27 | |
SU6656 is also a Src family kinase inhibitor, and by inhibiting Src kinases, it would impede the downstream signaling involved in actin cytoskeletal rearrangements, thus inhibiting the function of Cd302 in cell adhesion and migration processes. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor, which includes Src kinases. It would inhibit Cd302 by blocking the signaling pathways necessary for the regulation of cell adhesion and migration that require Cd302 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor, which can inhibit Cd302 function by blocking the p38 MAPK pathway that influences cell adhesion and migration, processes where Cd302 plays a role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which can inhibit Cd302 function by disrupting JNK signaling pathways that affect cell migration and adhesion, implicating Cd302's role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor, and by inhibiting Rho-associated protein kinase, it can disrupt actin cytoskeleton organization and cell motility, thereby inhibiting Cd302's function in these processes. | ||||||
PF-562271 | 717907-75-0 | sc-478488 sc-478488A sc-478488B | 5 mg 10 mg 50 mg | $312.00 $474.00 $1124.00 | 3 | |
PF-562271 is a focal adhesion kinase (FAK) inhibitor, which can inhibit Cd302 function by impeding the FAK signaling that is important for cell adhesion and migration, processes that involve Cd302. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide is an integrin inhibitor that can inhibit Cd302 function by blocking integrin-mediated signaling pathways that are essential for cell adhesion and migration, activities where Cd302 is implicated. | ||||||