CCDC66 Activators

Coiled-Coil Domain Containing 66 (CCDC66) is a protein that's encoded by the CCDC66 gene in humans. The term "coiled-coil" refers to a specific structural motif in proteins wherein alpha-helices are coiled together like the strands of a rope. This motif is involved in various functions, including protein-protein interactions and the regulation of gene expression.The CCDC66 protein is expressed in various tissues, suggesting it plays a broad role in human physiology. However, it has been particularly implicated in retinal diseases. A study in dogs identified a mutation in the CCDC66 gene associated with a form of progressive retinal atrophy, a disease that leads to blindness. Whether similar associations exist in humans remains to be explored.

In terms of cancer, there's evidence suggesting that CCDC66 may be involved in colorectal cancer progression. It has been identified as a potential biomarker, with its expression level correlating with disease stages.In summary, CCDC66 is a protein likely involved in protein-protein interactions due to its coiled-coil domain. While its exact function is not fully understood, it may play roles in retinal health and cancer progression.