Date published: 2026-4-28

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caspase-2 Substrates

Santa Cruz Biotechnology now offers a broad range of caspase-2 Substrates for use in various applications. Caspase-2 substrates are critical tools in the study of apoptosis, particularly in understanding the role of caspase-2 in the intrinsic pathway of cell death. Caspase-2 is one of the most conserved members of the caspase family, and it plays a unique role in the early stages of apoptosis, often acting as an initiator caspase that responds to cellular stress and DNA damage. By utilizing caspase-2 substrates, researchers can precisely monitor the activation of caspase-2, gaining insights into its function and the downstream effects of its activity. These substrates are widely employed in experiments designed to dissect the molecular mechanisms by which caspase-2 triggers the apoptotic process, as well as how it interacts with other proteins involved in cell death. In the scientific community, caspase-2 substrates are also used in high-throughput screening assays to identify novel modulators of caspase-2 activity, which can provide further understanding of its regulatory role in apoptosis. The ability to track caspase-2 activity using specific substrates allows for a deeper exploration of its involvement in maintaining cellular homeostasis and in the response to stress signals. This research is crucial for advancing our knowledge of the complex signaling networks that govern cell survival and death. View detailed information on our available caspase-2 Substrates by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ac-VDVAD-AFC

210344-94-8sc-311278
sc-311278A
5 mg
10 mg
$317.00
$525.00
(0)

Ac-VDVAD-AFC serves as a selective substrate for caspase-2, facilitating the study of its enzymatic activity through fluorescence resonance energy transfer (FRET). This compound exhibits unique specificity, allowing for the precise monitoring of caspase-2 activation in various cellular contexts. Its structural design promotes efficient cleavage, providing insights into the kinetics of proteolytic processes and the intricate regulation of apoptotic pathways.

Ac-VDVAD-pNA

189684-53-5sc-311279
sc-311279A
1 mg
5 mg
$54.00
$122.00
(0)

Ac-VDVAD-pNA is a synthetic peptide substrate tailored for caspase-2, characterized by its ability to undergo hydrolysis, releasing a chromogenic product. This compound's unique sequence enhances its affinity for caspase-2, enabling detailed kinetic studies of enzyme activity. The substrate's design allows for real-time monitoring of proteolytic events, shedding light on the dynamics of cellular signaling and the role of caspase-2 in apoptosis regulation.