caspase-13 Activators
Caspase-13 Activators are a curated group of chemical compounds that have been identified to enhance the functional activity of caspase-13, primarily through the modulation of cellular stress and apoptotic pathways. Compounds such as Sulforaphane and Oltipraz activate the Nrf2 pathway, leading to an upregulated antioxidant response, which can create cellular conditions that indirectly activate caspase-13, particularly during oxidative stress. Piperlongumine, by elevating reactive oxygen species (ROS) levels, and Betulinic Acid, through the induction of mitochondrial dysfunction, both serve to amplify apoptotic signals, thereby potentially enhancing caspase-13 activation.
Compounds like Fisetin and Curcumin exert their influence on apoptosis pathways, including the PI3K/Akt pathway, which can culminate in the activation of caspase-13. Similarly, Resveratrol and Quercetin, by modulating the SIRT1 pathway and directly inducing apoptosis respectively, can elevate caspase-13 activity as a component of the cell's programmed death machinery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide serves as a second messenger in cellular stress responses and can enhance the activation of Caspase-13 by promoting mitochondrial dysfunction and cytochrome c release, a process that leads to caspase activation. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid prevents the aggregation of misfolded proteins in the endoplasmic reticulum, which can lead to ER stress-induced apoptosis through Caspase-13 activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
This compound is a protein kinase C inhibitor that indirectly enhances Caspase-13 activation by modulating the PKC-mediated cell survival pathways, thereby allowing apoptotic signaling to proceed. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can have a regulatory effect on apoptosis. Though PKC usually promotes cell survival, in certain contexts, PKC activation can lead to the enhancement of Caspase-13 activity. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine can induce apoptosis through the mitochondrial pathway, which includes the activation of Caspase-13 as part of the caspase cascade leading to cell death. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can lead to apoptosis through a mitochondrial-dependent pathway that involves the activation of Caspase-13. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid is known to trigger the mitochondrial apoptosis pathway, involving the release of cytochrome c and subsequent activation of Caspase-13. | ||||||