casein kinase Iε Activators
Casein kinase Iε (CKIε) activators are a group of compounds specifically tailored to modulate the activity of the CKIε enzyme, one of the many members of the casein kinase I (CKI) family. These activators don't necessarily influence the expression or the abundance of CKIε protein itself but rather enhance or promote its enzyme activity. The CKI family, with CKIε as a representative member, is intricately involved in various cellular processes. These processes encompass a broad range from circadian rhythm regulation to DNA repair, membrane trafficking, and the canonical Wnt signaling pathway.
Understanding the mechanistic action of CKIε activators involves delving deeper into the biochemistry of kinase enzymes. Kinases transfer phosphate groups from high-energy donor molecules, like ATP, to specific substrates, often resulting in a functional change in the substrate. CKIε activators increase the efficiency of this phosphate transfer or increase the enzyme's affinity for its substrates. The precise mode of action for individual activators can vary, with some directly interacting with the active site, while others might act allosterically, modifying the enzyme's conformation to favor its active state. Consequently, the study and exploration of CKIε activators provide an avenue to decode the complex interplay of phosphorylation events in the cell, offering insights into cellular signaling, regulation, and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence gene transcription and has been shown to induce the expression of several genes. Its role in CKIε expression would be a potential modulation of the transcriptional machinery. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can activate the Wnt signaling pathway which may in turn influence the expression of downstream proteins, including possibly CKIε. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase leading to increased cAMP levels, which can modulate the transcription of certain genes potentially affecting CKIε expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can activate the glucocorticoid receptor, leading to altered gene transcription. This might have implications for proteins like CKIε. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound can inhibit DNA methyltransferases, leading to altered gene expression patterns, potentially affecting proteins like CKIε. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can influence chromatin structure and gene expression, potentially affecting CKIε expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can influence various signaling pathways and gene expression patterns, which might have an impact on proteins like CKIε. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate Nrf2 pathway leading to alteration in the expression of several genes. Its potential influence on CKIε expression is through the modulation of cellular stress response pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, can modulate various signaling pathways and affect gene expression, possibly influencing CKIε levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can affect various cell signaling pathways, including NF-κB and Wnt/β-catenin, potentially influencing the expression of proteins like CKIε. | ||||||