CARD 12 Activators
Caspase Recruitment Domain Family Member 12 (CARD12), also referred to as Nucleotide-binding Oligomerization Domain 9 (NOD9), is a protein belonging to the family of nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs). NLRs play pivotal roles in the innate immune system by detecting pathogen-associated molecular patterns (PAMPs) and initiating immune responses. CARD12 contains various functional domains, including a caspase recruitment domain (CARD) at its N-terminus, a nucleotide-binding domain (NBD), and leucine-rich repeat (LRR) motifs. These domains allow CARD12 to interact with signaling molecules and regulate downstream inflammatory pathways. The primary function of CARD12 is to activate nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) in response to microbial infection or cellular stress, leading to the production of pro-inflammatory cytokines and antimicrobial peptides.
Activation of CARD12 typically occurs through several mechanisms that involve its interaction with upstream regulators and downstream effectors in inflammatory signaling pathways. One common mechanism involves the recognition of PAMPs or danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs) on the cell surface or within the cytoplasm. Upon ligand binding, PRRs, such as Toll-like receptors (TLRs) or NOD-like receptors (NLRs), recruit adapter proteins, including CARD12, to form multiprotein signaling complexes known as inflammasomes or signalosomes. This recruitment leads to the oligomerization and activation of CARD12 through conformational changes, allowing it to interact with other signaling molecules and propagate downstream signaling events. Additionally, post-translational modifications, such as phosphorylation or ubiquitination, can also regulate CARD12 activity and contribute to its activation. Overall, activation of CARD12 represents a critical step in initiating innate immune responses and orchestrating the inflammatory cascade in response to microbial infection or cellular stress.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin, a flavonoid, activates CARD12 by modulating the NF-κB signaling pathway. It inhibits the degradation of IκBα, leading to the translocation of NF-κB into the nucleus and subsequent activation of CARD12. Luteolin's ability to enhance CARD12 activity is attributed to its indirect influence on the NF-κB pathway, highlighting its potential as a modulator of CARD12 in cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, activates CARD12 by influencing the SIRT1-AMPK pathway. Through activation of SIRT1, resveratrol enhances AMPK activity, resulting in the modulation of CARD12. This compound provides a novel perspective on the regulation of CARD12, showcasing the interconnectedness of cellular pathways and the potential for specific compounds to activate CARD12 through indirect mechanisms. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Fingolimod, also known as FTY720, activates CARD12 through the S1P receptor signaling pathway. By binding to S1P receptors, Fingolimod triggers downstream events that lead to the activation of CARD12. This compound sheds light on the role of sphingolipid signaling in CARD12 activation, presenting a unique avenue for modulating the protein's function in cellular processes. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid activates CARD12 by influencing the JNK signaling pathway. It enhances the phosphorylation of JNK, leading to the activation of CARD12. Betulinic Acid's ability to modulate CARD12 through the JNK pathway reveals a specific mechanism for regulating the protein's activity and provides insights into potential therapeutic strategies targeting this pathway to activate CARD12 in cellular processes. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin activates CARD12 through the calcium signaling pathway. By inducing calcium influx, Ionomycin triggers downstream events that result in the activation of CARD12. This compound highlights the role of calcium signaling in CARD12 activation, offering a distinct perspective on the modulation of CARD12 function in cellular processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMPK activator, indirectly activates CARD12 by modulating the AMPK signaling pathway. Through activation of AMPK, A769662 influences downstream events that lead to the activation of CARD12. This compound reveals a novel link between AMPK activation and CARD12 modulation, providing insights into the regulatory network governing CARD12 activity in cellular processes. | ||||||
Dioscin | 19057-60-4 | sc-497470 | 25 mg | $380.00 | ||
Dioscin activates CARD12 by influencing the PI3K-AKT signaling pathway. It enhances AKT phosphorylation, leading to the activation of CARD12. Dioscin's ability to modulate CARD12 through the PI3K-AKT pathway unveils a specific mechanism for regulating the protein's activity and provides insights into potential therapeutic strategies targeting this pathway to activate CARD12 in cellular processes. | ||||||
YODA 1 | 448947-81-7 | sc-507361 | 10 mg | $215.00 | ||
Yoda1 activates CARD12 through the Piezo1 channel signaling pathway. By activating Piezo1, Yoda1 triggers downstream events that lead to the activation of CARD12. This compound highlights the role of mechanosensitive ion channels in CARD12 activation, offering a distinct perspective on the modulation of CARD12 function in cellular processes. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Ivermectin activates CARD12 by modulating the STING-TBK1 signaling pathway. Through activation of STING-TBK1, Ivermectin influences downstream events that lead to the activation of CARD12. This compound provides a novel perspective on the regulation of CARD12, showcasing the interconnectedness of cellular pathways and the potential for specific compounds to activate CARD12 through indirect mechanisms. | ||||||