carbonyl reductase 2 Inhibitors
Carbonyl reductase 2 inhibitors are a class of molecules that specifically inhibit the activity of the carbonyl reductase 2 enzyme, a member of the short-chain dehydrogenase/reductase (SDR) family. CBR2 plays a significant role in the reduction of carbonyl compounds, catalyzing the conversion of a variety of aldehydes and ketones into their corresponding alcohols. This enzyme is involved in key metabolic pathways, including the detoxification of reactive carbonyl species and the metabolism of endogenous compounds such as steroids and prostaglandins. By inhibiting CBR2, these compounds interfere with the enzyme's ability to reduce carbonyl groups, affecting the overall balance of carbonyl compounds and alcohols in the cell.
CBR2 inhibitors function by binding to the active site of the enzyme, preventing it from interacting with its substrates. This inhibition disrupts the enzyme's role in cellular redox balance and the processing of carbonyl substrates, which can lead to the accumulation of reactive carbonyl species or shifts in metabolic pathways involving steroid and prostaglandin intermediates. These inhibitors are useful tools in studying the specific contributions of CBR2 to cellular metabolism, particularly in understanding how the reduction of carbonyl groups influences broader biochemical processes. Researchers use CBR2 inhibitors to explore the enzyme's function in redox homeostasis, carbonyl detoxification, and the regulation of metabolic intermediates. Through precise inhibition of CBR2, scientists gain insights into how carbonyl reductase enzymes affect various physiological pathways and how the regulation of carbonyl compounds contributes to cellular function and metabolic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 25 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
Direct inhibitor of carbonyl reductase 2, disrupting its NADPH-dependent oxidoreductase activity. Alters the reduction of carbonyl compounds, affecting various xenobiotics and prostaglandins metabolism. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Indirect inhibitor influencing carbonyl reductase 2 by disrupting estrogen signaling pathways. Alters the metabolism of carbonyl compounds, impacting xenobiotic responses within cells. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $40.00 | 8 | |
Inhibits carbonyl reductase 2 indirectly by interfering with the vitamin K epoxide reductase pathway. Alters the reduction of carbonyl compounds, affecting quinone metabolism within cells. | ||||||
Epalrestat | 82159-09-9 | sc-218319 | 10 mg | $200.00 | 2 | |
Direct inhibitor of carbonyl reductase 2, modulating its NADPH-dependent oxidoreductase activity. Alters the metabolism of carbonyl compounds, impacting prostaglandins and quinones. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Direct inhibitor of carbonyl reductase 2, influencing its NADPH-dependent oxidoreductase activity. Alters the reduction of carbonyl compounds, affecting xenobiotics and prostaglandins metabolism. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $90.00 $300.00 | 5 | |
Indirect inhibitor influencing carbonyl reductase 2 through disruption of glutathione metabolism. Alters the reduction of carbonyl compounds, impacting xenobiotics and quinones responses. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Indirect inhibitor affecting carbonyl reductase 2 through interference with the vitamin K epoxide reductase pathway. Alters the reduction of carbonyl compounds, impacting quinones metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Direct inhibitor of carbonyl reductase 2, influencing its NADPH-dependent oxidoreductase activity. Alters the reduction of carbonyl compounds, affecting xenobiotics and prostaglandins metabolism. | ||||||
2,6-Dihydroxybenzoic acid | 303-07-1 | sc-238412 sc-238412A sc-238412B | 25 g 100 g 500 g | $40.00 $104.00 $312.00 | ||
Indirect inhibitor influencing carbonyl reductase 2 through disruption of the glutathione metabolism. Alters the reduction of carbonyl compounds, impacting xenobiotics and quinones responses. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
Direct inhibitor of carbonyl reductase 2, modulating its NADPH-dependent oxidoreductase activity. Alters the reduction of carbonyl compounds, affecting xenobiotics and prostaglandins metabolism. | ||||||