Carbonyl reductase 1 Inhibitors
Carbonyl Reductase 1 (CBR1) is a key enzyme involved in the metabolism of a wide range of carbonyl-containing compounds, including xenobiotics and endogenous substrates. The inhibitors of CBR1 are diverse in their chemical structures and inhibition mechanisms. These inhibitors are crucial in studying the enzyme's role in drug metabolism and the development of novel strategies.
The inhibitors listed range from nonsteroidal anti-inflammatory drugs (NSAIDs) like flufenamic acid and indomethacin to natural flavonoids such as quercetin and morin. NSAIDs inhibit CBR1 by competing with substrates at the enzyme's active site, showcasing a typical reversible inhibition mechanism. Flavonoids, with their unique structures, also interact with CBR1, but their inhibition mechanisms might involve more complex interactions, including enzyme-bound coenzyme chelation or conformational changes in the enzyme's active site.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
A fenamate NSAID that inhibits CBR1 by competing with substrates at the enzyme's active site, reducing its activity through reversible binding. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
An NSAID that inhibits CBR1 by interacting with its active site, characterized by reversible binding which decreases the enzyme's catalytic efficiency. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
An anthracycline antibiotic that inhibits CBR1 indirectly by intercalating into DNA, affecting the enzyme's activity through cellular feedback mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A major green tea polyphenol that inhibits CBR1, likely through direct interaction and alteration of the enzyme's active site conformation. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Primarily a kinase inhibitor, it also shows CBR1 inhibition, possibly through off-target effects involving interactions with the enzyme's substrate-binding site. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
An antimicrobial agent that inhibits CBR1 by binding to its active site, demonstrating a noncompetitive inhibition mechanism. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
A dihydrofolate reductase inhibitor that also exhibits inhibitory effects on CBR1, likely by affecting enzyme binding sites and coenzyme availability. | ||||||
Clomiphene Citrate | 50-41-9 | sc-205636 sc-205636A | 1 g 5 g | $82.00 $173.00 | 1 | |
A nonsteroidal estrogen receptor antagonist that shows CBR1 inhibition, potentially through interactions with the enzyme's active site or allosteric sites. | ||||||