Carbonic Anhydrases Inhibitors
Items 11 to 17 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Chloro-2-fluorotoluene | 452-66-4 | sc-252260 | 5 ml | $39.00 | ||
5-Chloro-2-fluorotoluene demonstrates intriguing behavior as a carbonic anhydrase modulator through its ability to influence enzyme stability and substrate affinity. The presence of halogen substituents introduces steric effects that can alter the enzyme's active site geometry, enhancing or inhibiting catalytic efficiency. Its unique electronic properties may also affect proton transfer dynamics, leading to variations in reaction kinetics and influencing the equilibrium between carbon dioxide and bicarbonate. | ||||||
2-Aminobenzenesulfonamide | 3306-62-5 | sc-251694 | 5 g | $90.00 | ||
2-Aminobenzenesulfonamide exhibits notable characteristics as a carbonic anhydrase inhibitor, primarily through its ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This interaction can lead to conformational changes that disrupt the enzyme's catalytic cycle. Additionally, the sulfonamide group enhances its affinity for the zinc ion in the active site, modulating the enzyme's reactivity and influencing the balance of bicarbonate and carbon dioxide in physiological processes. | ||||||
Methazolamide | 554-57-4 | sc-235615 | 1 g | $92.00 | 3 | |
Methazolamide acts as a potent carbonic anhydrase inhibitor by engaging in specific electrostatic interactions with the enzyme's active site. Its unique structure allows for the formation of a stable complex with the zinc ion, which is crucial for enzyme activity. This binding alters the enzyme's conformation, effectively reducing its catalytic efficiency. The compound's distinct molecular geometry also influences its kinetic profile, impacting the rate of bicarbonate and proton exchange in biological systems. | ||||||
2,5-Dichlorothiophene-3-sulfonamide | 53595-68-9 | sc-231089 | 1 g | $160.00 | ||
Various sulfonamide derivatives have been explored as carbonic anhydrase inhibitors, and some may exhibit activity against CA8. | ||||||
trans-2-(4-Biphenyl)vinylboronic acid | 352530-23-5 | sc-255669 | 1 g | $44.00 | ||
Trans-2-(4-Biphenyl)vinylboronic acid exhibits unique interactions with carbonic anhydrases through its boronic acid moiety, which can form reversible covalent bonds with the enzyme's active site. This interaction stabilizes a transition state, enhancing the inhibition of the enzyme's catalytic function. The compound's planar biphenyl structure contributes to its hydrophobic interactions, influencing the enzyme's conformational dynamics and modulating reaction kinetics in bicarbonate hydration processes. | ||||||
Sulthiame | 61-56-3 | sc-474559 sc-474559A | 25 mg 250 mg | $350.00 $2448.00 | ||
Sulthiame acts as a potent inhibitor of carbonic anhydrases, characterized by its ability to disrupt the enzyme's zinc coordination. This disruption alters the enzyme's active site geometry, affecting substrate binding and catalysis. The compound's unique sulfonamide group facilitates strong hydrogen bonding with key amino acid residues, enhancing its inhibitory potency. Additionally, its lipophilic nature influences membrane permeability, potentially affecting enzyme localization and activity in cellular environments. | ||||||
Methyl bromopyruvate | 7425-63-0 | sc-235812 | 5 ml | $61.00 | ||
Methyl bromopyruvate serves as a selective inhibitor of carbonic anhydrases, exhibiting unique reactivity due to its electrophilic nature. The compound's carbonyl group engages in nucleophilic attack by the enzyme's active site, leading to the formation of a covalent adduct. This interaction alters the enzyme's conformation, impacting its catalytic efficiency. Furthermore, the presence of the bromine atom enhances molecular interactions, influencing the kinetics of enzyme inhibition and substrate competition. | ||||||